Cognitive impairment is frequent among symptomatic carriers of human T-cell lymphotropic virus type 1 (HTLV-1), regardless of their clinical status

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author GASCON, M. R. P. FMUSP-HC
CASSEB, J. FMUSP-HC
SMID, J.
VIDAL, J. E.
FONSECA, L. A. M. FMUSP-HC
PAIVA, A. FMUSP-HC
HAZIOT, M. J.
OLIVEIRA, A. C. Penalva de
dc.date.issued 2017
dc.description.abstract The main goal of this study was to investigate the presence of cognitive impairment in patients infected with HTLV-1 presenting or not TSP/HAM. Methods: Cross-sectional study including 104 participants: 37 asymptomatic HTLV-1 carriers, 37 patients diagnosed with TSP/HAM and 30 HTLV-1 negative control patients. Within the HTLV-1 positive group, 53 were female and 21 were male, the average age was 46 (SD = 13.5) and the average schooling time was 7.7 years (SD = 3.3).The sociodemographic variables (genre, age and education) were compared between the three groups. The assessment tools used were: Beck Depression Inventory, Lawton's Activities of Daily Life Scale and a complete neuropsychological battery. The application of these assessment tools was carried out in blind. Both HTLV-1 asymptomatic subjects and HAM/I'SP patients showed a lower performance on neuropsychological tests and higher depression scores when compared to the control group. HTLV-1 patients performed poorly in several cognitive domains, but only fluid intelligence, estimated intellectual functioning, immediate and delayed recall of visual memory and information processing speed (in the specific case of patients with TSP/HAM) reached statistical significance when compared with controls. Depression was not associated with cognitive impairment. HTLV-1 carriers presented a higher frequency of cognitive impairment than normal controls.
dc.description.group LIM/38
dc.description.group LIM/56
dc.description.index MEDLINE
dc.identifier.citation JOURNAL OF THE NEUROLOGICAL SCIENCES, v.377, p.185-189, 2017
dc.identifier.doi 10.1016/j.jns.2017.04.019
dc.identifier.eissn 1878-5883
dc.identifier.issn 0022-510X
dc.identifier.pmid 28477692
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/21620
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE BV
dc.relation.ispartof Journal of the Neurological Sciences
dc.rights restrictedAccess
dc.rights.holder Copyright ELSEVIER SCIENCE BV
dc.subject Neuropsychology; Depression; HTLV-1
dc.subject.other white-matter; depression; infection; dementia
dc.title Cognitive impairment is frequent among symptomatic carriers of human T-cell lymphotropic virus type 1 (HTLV-1), regardless of their clinical status
dc.type article
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author GASCON, M. R. P.:HC:ICHC
hcfmusp.author CASSEB, J.:IMT:DVCIENT-83
hcfmusp.author FONSECA, L. A. M.:HC:ICHC
hcfmusp.author PAIVA, A.:IMT:
hcfmusp.author.external · SMID, J.:Inst Infect Dis Emilio Ribas, Sao Paulo, Brazil
· VIDAL, J. E.:Inst Infect Dis Emilio Ribas, Sao Paulo, Brazil
· HAZIOT, M. J.:Inst Infect Dis Emilio Ribas, Sao Paulo, Brazil
· OLIVEIRA, A. C. Penalva de:Inst Infect Dis Emilio Ribas, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000401879000037
hcfmusp.publisher.city AMSTERDAM
hcfmusp.publisher.country NETHERLANDS
hcfmusp.relation.reference · Alexopoulos GS, 2002, AM J GERIAT PSYCHIAT, V10, P98, DOI 10.1176/appi.ajgp.10.1.98
· Araujo AQC, 2009, ARQ NEURO-PSIQUIAT, V67, P132, DOI 10.1590/S0004-282X2009000100036
· Araujo Abelardo Q-C, 2015, Curr Infect Dis Rep, V17, P459, DOI 10.1007/s11908-014-0459-0
· Brucki SMD, 1997, ARQ NEURO-PSIQUIAT, V55, P56
· Cartier R Luis, 2009, Rev. chil. neuro-psiquiatr., V47, P50, DOI 10.4067/S0717-92272009000100007
· Champs Ana Paula Silva, 2013, Dement. neuropsychol., V7, P439, DOI 10.1590/S1980-57642013DN74000014
· Diniz LFM, 2000, REV BRAS NEUROL, V36, P79
· DSM-V, 2015, MAN DIAGN EST TRANST
· Filley CM, 1998, NEUROLOGY, V50, P1535
· Gessain A, 2011, Bull Soc Pathol Exot, V104, P167, DOI 10.1007/s13149-011-0174-4
· Gorestein C., 2012, BDI 2 INVENTARIO BEC
· Henrique Iara Ferraz Silva, 2004, Rev. Assoc. Med. Bras., V50, P199, DOI 10.1590/S0104-42302004000200039
· KATZMAN R, 1993, NEUROLOGY, V43, P13
· Laks J., 1999, REV BRAS NEUROL, V35, P97
· LAWTON MP, 1969, GERONTOLOGIST, V9, P179
· Mendes G. B., 2014, INT J INFECT DIS, P251
· Mesulam M., 2000, PRINCIPLES BEHAV COG, P41
· Morgan DJ, 2007, AIDS RES HUM RETROV, V23, P1499, DOI 10.1089/aid.2007.0077
· NITRINI R, 1994, ARQ NEURO-PSIQUIAT, V52, P457
· Palsson S, 2000, ACTA PSYCHIAT SCAND, V101, P185, DOI 10.1034/j.1600-0447.2000.101003185.x
· Portella MJ, 2002, REV NEUROLOGIA, V35, P891
· Puccioni-Sohler M, 2012, ARQ NEURO-PSIQUIAT, V70, P246, DOI 10.1590/S0004-282X2012000400004
· Rabelo I. S., 2010, TESTE TRILHAS COLORI
· Rey A., 2010, FIGURAS COMPLEXAS RE
· Romanelli L. C. F., 2011, REV CIE MED PERNAMBU, V7
· Silva MTT, 2003, J NEUROL NEUROSUR PS, V74, P1085, DOI 10.1136/jnnp.74.8.1085
· Spreen O., 1998, COMPENDIUM NEUROPSYC
· TOURNIERLASSERVE E, 1987, LANCET, V2, P49
· Wechsler D., 2004, WAIS 3 ESCALA INTELI
hcfmusp.source 2-s2.0-85018496312


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