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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorBOCCHI, Edimar Alcides-
dc.contributor.authorBESTETTI, Reinaldo Bulgarelli-
dc.contributor.authorSCANAVACCA, Mauricio Ibrahim-
dc.contributor.authorNETO, Edecio Cunha-
dc.contributor.authorISSA, Victor Sarli-
dc.date.accessioned2017-10-24T13:16:49Z-
dc.date.available2017-10-24T13:16:49Z-
dc.date.issued2017-
dc.identifier.citationJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v.70, n.12, p.1510-1524, 2017-
dc.identifier.issn0735-1097-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21847-
dc.description.abstractTrypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T. cruzi infection is crucial. Several biomarkers have been reported in Chagas heart disease (ChHD), but most are nonspecific for T. cruzi infection. Prognosis of ChHD patients is worse compared with other etiologies, with sudden cardiac death as an important mode of death. Most ChHD patients display diffuse myocarditis with fibrosis and hypertrophy. The remodeling process seems to be associated with etiopathogenic mechanisms and neurohormonal activation. Pharmacological treatment and antiarrhythmic therapy for ChHD is mostly based on results for other etiologies. Heart transplantation is an established, valuable therapeutic option in refractory ChHD. Implantable cardioverter-defibrillators are indicated for prevention of secondary sudden cardiac death. Specific etiological treatments should be revisited and reserved for select patients. Understanding and management of ChHD need improvement, including development of randomized trials. (C) 2017 by the American College of Cardiology Foundation.-
dc.description.sponsorshipServier-
dc.description.sponsorshipAstraZeneca-
dc.language.isoeng-
dc.publisherELSEVIER SCIENCE INC-
dc.relation.ispartofJournal of the American College of Cardiology-
dc.rightsrestrictedAccess-
dc.subjectheart failure-
dc.subjectheart transplantation-
dc.subjectprognosis-
dc.subjectsudden death-
dc.subjectTrypanosoma cruzi-
dc.subject.otherimplantable cardioverter-defibrillator-
dc.subject.otherterm-follow-up-
dc.subject.othersudden cardiac death-
dc.subject.otherleft-ventricular dysfunction-
dc.subject.otherbrain natriuretic peptide-
dc.subject.othertrypanosoma-cruzi dna-
dc.subject.otherall-cause mortality-
dc.subject.otherdilated cardiomyopathy-
dc.subject.otheratrial-fibrillation-
dc.subject.otherprimary prevention-
dc.titleChronic Chagas Heart Disease Management From Etiology to Cardiomyopathy Treatment-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCIENCE INC-
dc.identifier.doi10.1016/j.jacc.2017.08.004-
dc.identifier.pmid28911515-
dc.subject.wosCardiac & Cardiovascular Systems-
dc.type.categoryreview-
dc.type.versionpublishedVersion-
hcfmusp.author.externalBESTETTI, Reinaldo Bulgarelli:Univ Ribeirao Preto, Dept Med, Sao Paulo, Brazil-
hcfmusp.description.beginpage1510-
hcfmusp.description.endpage1524-
hcfmusp.description.issue12-
hcfmusp.description.volume70-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-85029475715-
hcfmusp.origem.idWOS:000410172700012-
hcfmusp.publisher.cityNEW YORK-
hcfmusp.publisher.countryUSA-
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dc.description.indexMEDLINE-
dc.identifier.eissn1558-3597-
hcfmusp.citation.scopus135-
hcfmusp.scopus.lastupdate2024-03-29-
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Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MCP
Departamento de Cardio-Pneumologia - FM/MCP

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