Clinical, histological and radiological responses to methylprednisolone in HIV-associated rod myopathy

Imagem de Miniatura
Arquivos
art_SILVA_Clinical_histological_and_radiological_responses_to_methylprednisolone_in_2017.PDF (1.27 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
Citação
NEUROMUSCULAR DISORDERS, v.27, n.8, p.756-759, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Skeletal muscle involvement as a neurologic manifestation in individuals with HIV is rare, especially as rod myopathy. We describe a 41-year-old male with HIV infection who presented progressive proximal muscle weakness and limb-girdle atrophy. A muscle magnetic resonance image showed bilateral fatty infiltration and post-contrast enhancement in the arm and thigh muscles. The muscle biopsy revealed intracytoplasmic aggregates with appearance of nemaline rod bodies with Gomori trichrome staining and electron microscopy in most fibers. The patient underwent six cycles of intravenous methylprednisolone pulses, presenting clinical improvement. Post-treatment muscle biopsy showed fewer nemaline bodies and muscle magnetic resonance image depicted a pronounced reduction of muscular edema. These findings corroborate that deposition of nemaline bodies in these patients might be related to an immune response triggered by the virus.
Palavras-chave
Sporadic late-onset nemaline myopathy (SLONM), Rod myopathy, HIV infection, Inflammatory myopathy, Muscle MRI
URI
https://observatorio.fm.usp.br/handle/OPI/21926
Referências
  1. Authier FJ, 2005, MUSCLE NERVE, V32, P247, DOI 10.1002/mus.20338
  2. Benveniste O, 2008, NEUROLOGY, V71, P531, DOI 10.1212/01.wnl.0000310813.79325.32
  3. Chahin N, 2005, NEUROLOGY, V65, P1158, DOI 10.1212/01.wnl.0000180362.90078.dc
  4. Costa AF, 2012, MUSCLE NERVE, V46, P465, DOI 10.1002/mus.23370
  5. Dalakas MC, 2008, NEUROLOGY, V71, P472, DOI 10.1212/01.wnl.0000324861.44410.be
  6. DALAKAS MC, 1987, NEW ENGL J MED, V317, P1602
  7. de Sanctis JT, 2008, AIDS READ, V18, P90
  8. Madonia Phillip, 2012, J La State Med Soc, V164, P320
  9. Tasca G, 2015, MUSCLE NERVE, V52, P956, DOI 10.1002/mus.24661
  10. Voermans NC, 2008, NEUROLOGY, V71, P532, DOI 10.1212/01.wnl.0000310814.54623.6f
  11. Voermans NC, 2014, NEUROLOGY, V83, P2133, DOI 10.1212/WNL.0000000000001047

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/45
Artigos e Materiais de Revistas Científicas - ODS/03