Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/21963
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SIMOES, Ricardo Santos | - |
dc.contributor.author | SOARES- JR., Jose Maria | - |
dc.contributor.author | SIMOES, Manuel J. | - |
dc.contributor.author | NADER, Helena B. | - |
dc.contributor.author | BARACAT, Maria Candida P. | - |
dc.contributor.author | MACIEL, Gustavo Arantes R. | - |
dc.contributor.author | SERAFINI, Paulo C. | - |
dc.contributor.author | AZZIZ, Ricardo | - |
dc.contributor.author | BARACAT, Edmund C. | - |
dc.date.accessioned | 2017-10-24T13:20:30Z | - |
dc.date.available | 2017-10-24T13:20:30Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | JOURNAL OF OVARIAN RESEARCH, v.10, article ID 54, 8p, 2017 | - |
dc.identifier.issn | 1757-2215 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/21963 | - |
dc.description.abstract | Background: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. Methods: In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase. The study subjects were matched for age, body mass index and race. The age range was 20 to 35 years. All volunteers were evaluated in reproductive endocrinology clinic, Gynecology Division, Clinics Hospital, University of Sao Paulo Medical School Profile and concentration of small leucine-rich proteoglycans (decorin, lumican, fibromodulin and biglycan) were determined by immunohistochemical testing and Western blotting. Results: Decorin and lumican demonstrated higher immunoreactivity and relative expression in the endometrium of women with PCOS compared to that of women with regular menstrual cycles. Conclusion: Our data suggests that the endometrium of PCOS women demonstrate a greater content of SLRP than controls; decorin and lumican, in particular, were found in higher concentrations in the endometrium of PCOS women during the proliferative phase. These differences may, in part, explain the excess of endometrial proliferation frequently observed in PCOS. Further studies are warranted. | - |
dc.description.sponsorship | FAPESP (Brasilia - Brazil) [Fapesp 2009/54019-9] | - |
dc.description.sponsorship | CAPES (Brasilia - Brazil) | - |
dc.language.iso | eng | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.relation.ispartof | Journal of Ovarian Research | - |
dc.rights | openAccess | - |
dc.subject | Polycystic ovary syndrome | - |
dc.subject | Endometrium | - |
dc.subject | Small leucine-rich proteoglycans | - |
dc.subject | Proliferative phase | - |
dc.subject.other | collagen fibrillogenesis | - |
dc.subject.other | cell-proliferation | - |
dc.subject.other | decorin | - |
dc.subject.other | expression | - |
dc.subject.other | cancer | - |
dc.subject.other | implantation | - |
dc.subject.other | criteria | - |
dc.subject.other | lumican | - |
dc.subject.other | insulin | - |
dc.subject.other | growth | - |
dc.title | Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study | - |
dc.type | article | - |
dc.rights.holder | Copyright BIOMED CENTRAL LTD | - |
dc.identifier.doi | 10.1186/s13048-017-0349-9 | - |
dc.identifier.pmid | 28789706 | - |
dc.subject.wos | Reproductive Biology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SIMOES, Manuel J.:Univ Sao Paulo, Fac Med, Disciplina Ginecol, Dept Obstet & Ginecol,Hosp Clin, Sao Paulo, Brazil | - |
hcfmusp.author.external | NADER, Helena B.:Univ Fed Sao Paulo, Dept Mol Biol, Sao Paulo, Brazil | - |
hcfmusp.author.external | AZZIZ, Ricardo:Augusta Univ, Med Coll Georgia, Dept Obstet & Gynecol, Augusta, GA USA; Augusta Univ, Med Coll Georgia, Dept Med, Augusta, GA USA | - |
hcfmusp.description.articlenumber | 54 | - |
hcfmusp.description.volume | 10 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000407714300001 | - |
hcfmusp.origem.id | 2-s2.0-85026898773 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
hcfmusp.relation.reference | Andrade P. M., 2000, Clinical and Experimental Obstetrics and Gynecology, V27, P138 | - |
hcfmusp.relation.reference | Apparao KBC, 2002, BIOL REPROD, V66, P297, DOI 10.1095/biolreprod66.2.297 | - |
hcfmusp.relation.reference | Azziz R, 2006, J CLIN ENDOCR METAB, V91, P4237, DOI 10.1210/jc.2006-0178 | - |
hcfmusp.relation.reference | Azziz R, 2016, FERTIL STERIL, V106, P4, DOI 10.1016/j.fertnstert.2016.05.009 | - |
hcfmusp.relation.reference | BALEN AH, 1995, HUM REPROD, V10, P2107 | - |
hcfmusp.relation.reference | Baracat MCP, 2015, INT J GYNECOL OBSTET, V129, P1, DOI 10.1016/j.ijgo.2014.10.022 | - |
hcfmusp.relation.reference | Barry JA, 2014, HUM REPROD UPDATE, V20, P748, DOI 10.1093/humupd/dmu012 | - |
hcfmusp.relation.reference | Cheung AP, 2001, OBSTET GYNECOL, V98, P325, DOI 10.1016/S0029-7844(01)01432-6 | - |
hcfmusp.relation.reference | Christ JP, 2014, FERTIL STERIL, V101, P280, DOI 10.1016/j.fertnstert.2013.10.001 | - |
hcfmusp.relation.reference | Coulson-Thomas VJ, 2013, EXP CELL RES, V319, P967, DOI 10.1016/j.yexcr.2013.01.023 | - |
hcfmusp.relation.reference | Fauser BCJM, 2004, HUM REPROD, V19, P41, DOI 10.1093/humrep/deh098 | - |
hcfmusp.relation.reference | Fraser IS, 2011, SEMIN REPROD MED, V29, P383, DOI 10.1055/s-0031-1287662 | - |
hcfmusp.relation.reference | Gadducci A, 2005, GYNECOL ENDOCRINOL, V20, P200, DOI 10.1080/09513590400021201 | - |
hcfmusp.relation.reference | Giordano MV, 2015, GYNECOL ENDOCRINOL, V31, P278, DOI 10.3109/09513590.2014.989980 | - |
hcfmusp.relation.reference | Giudice LC, 2006, BEST PRACT RES CL EN, V20, P235, DOI 10.1016/j.beem.2006.03.005 | - |
hcfmusp.relation.reference | HILDEBRAND A, 1994, BIOCHEM J, V302, P527 | - |
hcfmusp.relation.reference | Hull M G, 1987, Gynecol Endocrinol, V1, P235, DOI 10.3109/09513598709023610 | - |
hcfmusp.relation.reference | Iatrakis G, 2006, EUR J OBSTET GYN R B, V127, P218, DOI 10.1016/j.ejogrb.2006.01.023 | - |
hcfmusp.relation.reference | Iozzo RV, 2011, J CELL MOL MED, V15, P1013, DOI 10.1111/j.1582-4934.2010.01236.x | - |
hcfmusp.relation.reference | Iozzo RV, 1997, CRIT REV BIOCHEM MOL, V32, P141, DOI 10.3109/10409239709108551 | - |
hcfmusp.relation.reference | Kaaks R, 2001, Gynecol Obstet Fertil, V29, P185, DOI 10.1016/S1297-9589(00)00047-3 | - |
hcfmusp.relation.reference | Kitaya K, 2009, J LEUKOCYTE BIOL, V85, P391, DOI 10.1189/jlb.0908535 | - |
hcfmusp.relation.reference | Lala PK, 2016, CELL ADHES MIGR, V10, P111, DOI 10.1080/19336918.2015.1106669 | - |
hcfmusp.relation.reference | Lizneva D, 2016, FERTIL STERIL, V106, P6, DOI 10.1016/j.fertnstert.2016.05.003 | - |
hcfmusp.relation.reference | MAUVIEL A, 1995, J BIOL CHEM, V270, P11692, DOI 10.1074/jbc.270.19.11692 | - |
hcfmusp.relation.reference | Niu C, 2012, INT J CANCER, V130, P2549, DOI 10.1002/ijc.26259 | - |
hcfmusp.relation.reference | Noyes R W, 1975, Am J Obstet Gynecol, V122, P262 | - |
hcfmusp.relation.reference | Ono YJ, 2014, J ENDOCRINOL, V223, P203, DOI 10.1530/JOE-14-0393 | - |
hcfmusp.relation.reference | Pillay OC, 2006, HUM REPROD, V21, P924, DOI 10.1093/humrep/dei420 | - |
hcfmusp.relation.reference | RADA JA, 1993, EXP EYE RES, V56, P635, DOI 10.1006/exer.1993.1081 | - |
hcfmusp.relation.reference | RANDOLPH JF, 1987, AM J OBSTET GYNECOL, V157, P1534 | - |
hcfmusp.relation.reference | Lopes IMRS, 2014, REPROD SCI, V21, P930, DOI 10.1177/1933719113519169 | - |
hcfmusp.relation.reference | Lopes IMRS, 2011, REV ASSOC MED BRAS, V57, P702, DOI 10.1590/S0104-42302011000600020 | - |
hcfmusp.relation.reference | Roemer KL, 2014, J CLIN ENDOCR METAB, V99, pE2162, DOI 10.1210/jc.2014-2128 | - |
hcfmusp.relation.reference | Rutanen EM, 1998, GYNECOL ENDOCRINOL, V12, P399, DOI 10.3109/09513599809012842 | - |
hcfmusp.relation.reference | Salgado RM, 2011, REPROD BIOL ENDOCRIN, V9, DOI 10.1186/1477-7827-9-22 | - |
hcfmusp.relation.reference | San Martin S, 2003, REPRODUCTION, V125, P585, DOI 10.1530/rep.0.1250585 | - |
hcfmusp.relation.reference | Seidler DG, 2008, IUBMB LIFE, V60, P729, DOI 10.1002/iub.115 | - |
hcfmusp.relation.reference | Vij N, 2004, EXP EYE RES, V78, P957, DOI 10.1016/j.exer.2003.12.006 | - |
hcfmusp.relation.reference | VOGEL KG, 1987, COLLAGEN REL RES, V7, P105 | - |
hcfmusp.relation.reference | VOGEL KG, 1984, BIOCHEM J, V223, P587 | - |
hcfmusp.relation.reference | YAMAGUCHI Y, 1988, NATURE, V336, P244, DOI 10.1038/336244a0 | - |
dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 10 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MOG Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/58 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_SIMOES_Small_leucinerich_proteoglycans_SLRPs_in_the_endometrium_of_2017.PDF | publishedVersion (English) | 4.51 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.