Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/22016
Title: Compensatory lung growth after bilobectomy in emphysematous rats
Authors: ALMEIDA, Francine MariaSARAIVA-ROMANHOLO, Beatriz MangueiraVIEIRA, Rodolfo PaulaMORIYA, Henrique TakachiLIGEIRO-DE-OLIVEIRA, Ana PaulaLOPES, Fernanda D. T. Q. S.CASTRO-FARIA-NETO, Hugo C.MAUAD, ThaisMARTINS, Milton ArrudaPAZETTI, Rogerio
Citation: PLOS ONE, v.12, n.7, article ID e181819, 14p, 2017
Abstract: Lung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair.
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - FM/MPT
Departamento de Patologia - FM/MPT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/InCor
Instituto do Coração - HC/InCor

Artigos e Materiais de Revistas Científicas - LIM/05
LIM/05 - Laboratório de Poluição Atmosférica Experimental

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LIM/20 - Laboratório de Terapêutica Experimental

Artigos e Materiais de Revistas Científicas - LIM/61
LIM/61 - Laboratório de Pesquisa em Cirurgia Torácica


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