Ultrastructural Evaluation of Eutopic Endometrium of Infertile Women With and Without Endometriosis During the Window of Implantation: A Pilot Study

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Citações na Scopus
14
Tipo de produção
article
Data de publicação
2017
Editora
SAGE PUBLICATIONS INC
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
BROI, Michele G. Da
ROCHA JR., Carlos V.
MARTINS, Wellington P.
FERRIANI, Rui A.
NAVARRO, Paula A.
Autor de Grupo de pesquisa
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Organizadores
Citação
REPRODUCTIVE SCIENCES, v.24, n.10, p.1469-1475, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Endometriosis is frequently associated with infertility and it is believed that the impairment of endometrial receptivity may be one of the mechanisms involved in this condition. Pinopodes are endometrial cycle-dependent structures that seem to participate in embryo implantation, and alterations in their presence and/or morphology during the window of implantation could affect the endometrial receptivity and be involved in the disease-related infertility. However, the data on pinopodes in these women are scarce and inconclusive. This pilot study aimed to evaluate the cell pattern, including the presence and developmental stage of pinopodes, in eutopic endometrium of infertile patients with and without endometriosis during the window of implantation, using scanning electron microscopy (SEM). Endometrial biopsies were performed using a Pipelle catheter, and 12 samples classified in the window of implantation (6 infertile women with endometriosis and 6 infertile controls) were analyzed by SEM. The frequencies of cell types (microvilli, ciliated, and pinopodes) and the developmental stage of pinopodes were compared between groups using Mann-Whitney U test. Although the study was limited by its sample size, no large differences were detected between the groups regarding the presence and developmental stage of pinopodes, suggesting the absence of large structural changes in the endometrium of infertile women with endometriosis during the window of implantation.
Palavras-chave
endometriosis, female infertility, endometrial receptivity, pinopodes
Referências
  1. Achache H, 2006, HUM REPROD UPDATE, V12, P731, DOI 10.1093/humupd/dml004
  2. Acosta AA, 2000, FERTIL STERIL, V73, P788, DOI 10.1016/S0015-0282(99)00605-6
  3. Agarwal A, 2005, REPROD BIOL ENDOCRIN, V3, DOI 10.1186/1477-7827-3-28
  4. Agarwal A, 2006, REPROD BIOMED ONLINE, V13, P126
  5. Aghajanova L, 2009, BIOL REPROD, V80, P105, DOI 10.1095/biolreprod.108.070300
  6. Aghajanova L, 2003, FERTIL STERIL, V79, P808, DOI 10.1016/S0015-0282(02)04830-6
  7. Alizadeh Zohreh, 2011, Iranian Biomedical Journal, V15, P66
  8. Attia GR, 2000, J CLIN ENDOCR METAB, V85, P2897, DOI 10.1210/jc.85.8.2897
  9. Bagot CN, 2001, DEV DYNAM, V222, P538, DOI 10.1002/dvdy.1209
  10. Bedaiwy MA, 2015, REPROD SCI, V22, P1153, DOI 10.1177/1933719115585145
  11. Bulletti C, 2010, J ASSIST REPROD GEN, V27, P441, DOI 10.1007/s10815-010-9436-1
  12. Burney RO, 2012, FERTIL STERIL, V98, P511, DOI 10.1016/j.fertnstert.2012.06.029
  13. Cakmak H, 2011, HUM REPROD UPDATE, V17, P242, DOI 10.1093/humupd/dmq037
  14. Cakmak H, 2010, SEMIN REPROD MED, V28, P69, DOI 10.1055/s-0029-1242996
  15. Canis M, 1997, FERTIL STERIL, V67, P817
  16. Cho S, 2009, AM J REPROD IMMUNOL, V61, P286, DOI 10.1111/j.1600-0897.2009.00692.x
  17. Cohen J, 1988, STAT POWER ANAL BEHA
  18. Fraser IS, 2007, FERTIL STERIL, V87, P466, DOI 10.1016/j.fertnstert.2007.01.023
  19. Garcia-Velasco JA, 2001, FERTIL STERIL, V75, P1231, DOI 10.1016/S0015-0282(01)01774-5
  20. Giudice LC, 2004, LANCET, V364, P1789, DOI 10.1016/S0140-6736(04)17403-5
  21. Giudice LC, 2002, ANN NY ACAD SCI, V955, P252
  22. Giudice LC, 2002, ANN NY ACAD SCI, V955, P293
  23. Giudice LC, 2002, ANN NY ACAD SCI, V955, P396
  24. Gupta S, 2008, FERTIL STERIL, V90, P247, DOI 10.1016/j.fertnstert.2008.02.093
  25. Holoch KJ, 2010, CLIN OBSTET GYNECOL, V53, P429, DOI 10.1097/GRF.0b013e3181db7d71
  26. Hoozemans DA, 2004, REPROD BIOMED ONLINE, V9, P692
  27. Kao LC, 2003, ENDOCRINOLOGY, V144, P2870, DOI 10.1210/en.2003-0043
  28. LESSEY BA, 1994, J CLIN ENDOCR METAB, V79, P643, DOI 10.1210/jc.79.2.643
  29. LESSEY BA, 1992, J CLIN INVEST, V90, P188, DOI 10.1172/JCI115835
  30. Makrigiannakis A, 2009, HISTOCHEM CELL BIOL, V132, P159, DOI 10.1007/s00418-009-0593-1
  31. Matsuzaki S, 2006, FERTIL STERIL, V85, P308, DOI 10.1016/j.fertnstert.2005.08.017
  32. Matsuzaki S, 2010, HUM REPROD, V25, P742, DOI 10.1093/humrep/dep435
  33. Minjarez DA, 2000, OBSTET GYN CLIN N AM, V27, P641, DOI 10.1016/S0889-8545(05)70161-3
  34. Moberg C, 2015, ARCH GYNECOL OBSTET, V292, P429, DOI 10.1007/s00404-015-3626-0
  35. Nardo LG, 2002, EUR J OBSTET GYN R B, V101, P104, DOI 10.1016/S0301-2115(01)00523-1
  36. Nikas G, 1999, HUM REPROD, V14, P99
  37. Nikas G, 2000, SEMIN REPROD MED, V18, P229, DOI 10.1055/s-2000-12561
  38. Nikas G, 2003, ANN NY ACAD SCI, V997, P120, DOI 10.1196/annuals.1290.042
  39. Nikas G, 1997, ANN NY ACAD SCI, V816, P129, DOI 10.1111/j.1749-6632.1997.tb52136.x
  40. Nikas G, 2000, ANN NY ACAD SCI, V900, P316
  41. Noyes R W, 1975, Am J Obstet Gynecol, V122, P262
  42. Ordi J, 2003, J ASSIST REPROD GEN, V20, P465, DOI 10.1023/B:JARG.0000006709.61216.6f
  43. Osteen KG, 1999, GYNECOL OBSTET INVES, V48, P2, DOI 10.1159/000052863
  44. Practice Comm Amer Soc Reprod Med, 2012, FERTIL STERIL, V98, P591, DOI 10.1016/j.fertnstert.2012.05.031
  45. Quinn CE, 2009, HUM REPROD UPDATE, V15, P229, DOI 10.1093/humupd/dmn052
  46. Quinn C, 2007, FERTIL STERIL, V87, P1015, DOI 10.1016/i.fertnstert.2006.08.101
  47. Sharkey AM, 2003, BEST PRACT RES CL OB, V17, P289, DOI 10.1053/ybeog.2003.352
  48. Sharma Alok, 2012, J Hum Reprod Sci, V5, P2, DOI 10.4103/0974-1208.97777
  49. Shen FR, 2015, ARCH GYNECOL OBSTET, V291, P439, DOI 10.1007/s00404-014-3419-x
  50. Sugawara J, 1997, FERTIL STERIL, V68, P468, DOI 10.1016/S0015-0282(97)00226-4
  51. Surrey ES, 2007, J ASSIST REPROD GEN, V24, P553, DOI 10.1007/s10815-007-9164-3
  52. Taylor HS, 1999, HUM REPROD, V14, P1328, DOI 10.1093/humrep/14.5.1328
  53. Usadi RS, 2003, FERTIL STERIL, V79, P970, DOI 10.1016/S0015-0282(02)04929-4
  54. Wei QX, 2009, FERTIL STERIL, V91, P1686, DOI 10.1016/j.fertnstert.2008.02.121
  55. Wilcox AJ, 1999, NEW ENGL J MED, V340, P1796, DOI 10.1056/NEJM199906103402304
  56. Xu BF, 2012, FERTIL STERIL, V98, P389, DOI 10.1016/j.fertnstert.2012.04.032
  57. [Anonymous], 2006, FERTIL STERIL S1, V86, pS156