Regulatory T-Cell Distribution within Lung Compartments in COPD

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SALES, Davi S. FMUSP-HC
ITO, Juliana T. FMUSP-HC
ZANCHETTA, Ivy A.
ANNONI, Raquel FMUSP-HC
AUN, Marcelo V. FMUSP-HC
FERRAZ, Luiz Fernando S.
CERVILHA, Daniela A. B. FMUSP-HC
NEGRI, Elnara FMUSP-HC
MAUAD, Thais FMUSP-HC
MARTINS, Milton A. FMUSP-HC
LOPES, Fernanda D. T. Q. S. FMUSP-HC
dc.date.issued 2017
dc.description.abstract The importance of the adaptive immune response, specifically the role of regulatory T (Treg) cells in controlling the obstruction progression in smokers, has been highlighted. To quantify the adaptive immune cells in different lung compartments, we used lung tissues from 21 never-smokers without lung disease, 22 current and/or ex-smokers without lung disease (NOS) and 13 current and/or ex-smokers with chronic obstructive pulmonary disease (COPD) for histological analysis. We observed increased T, B, IL-17 and BAFF(+) cells in small and large airways of COPD individuals; however, in the NOS, we only observed increase in T and IL-17(+) cells only in small airways. A decrease in the density of Treg(+), TGF-beta(+) and IL-10(+) in small and large airways was observed only in COPD individuals. In the lymphoid tissues, Treg, T,B-cells and BAFF(+) cells were also increased in COPD; however, changes in Treg inhibitory associated cytokineswere not observed in this compartment. Therefore, our results suggest that difference in Treg(+) cell distributions in lung compartments and the decrease in TGF-beta(+) and IL-10(+) cells in the airways may lead to the obstruction in smokers.
dc.description.group LIM/05
dc.description.group LIM/59
dc.description.group LIM/20
dc.description.index MEDLINE
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/15819-8]
· Ministerio da Ciencia, Tecnologia e Inovacao - Conselho Nacional de Pesquisa (CNPq) [442679/2014-9]
dc.identifier.citation COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, v.14, n.5, p.533-542, 2017
dc.identifier.doi 10.1080/15412555.2017.1346069
dc.identifier.eissn 1541-2563
dc.identifier.issn 1541-2555
dc.identifier.pmid 28745532
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/22019
dc.language.iso eng
dc.publisher TAYLOR & FRANCIS INC
dc.relation.ispartof Copd-Journal of Chronic Obstructive Pulmonary Disease
dc.rights restrictedAccess
dc.rights.holder Copyright TAYLOR & FRANCIS INC
dc.subject Adaptive immunity; COPD; interleukin-10; T-cells; regulatory T-cells; TGF-beta
dc.subject.other obstructive pulmonary-disease; tgf-beta; induced emphysema; peripheral-blood; tobacco smoking; smokers; expression; lymphocytes; follicles; foxp3
dc.title Regulatory T-Cell Distribution within Lung Compartments in COPD
dc.type article
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SALES, Davi S.:FM:
hcfmusp.author ITO, Juliana T.:FM:
hcfmusp.author ANNONI, Raquel:HC:LIM/05
hcfmusp.author AUN, Marcelo V.:FM:
hcfmusp.author CERVILHA, Daniela A. B.:FM:
hcfmusp.author NEGRI, Elnara:HC:LIM/59
hcfmusp.author MAUAD, Thais:FM:MPT
hcfmusp.author MARTINS, Milton A.:FM:MCM
hcfmusp.author LOPES, Fernanda D. T. Q. S.:HC:LIM/20
hcfmusp.author.external · ZANCHETTA, Ivy A.:Univ Sao Paulo, Sch Med, Dept Med, Lab Expt Therapeut LIM 20, Sao Paulo, Brazil
· FERRAZ, Luiz Fernando S.:Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000409549000012
hcfmusp.publisher.city PHILADELPHIA
hcfmusp.publisher.country USA
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hcfmusp.source 2-s2.0-85026251041


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