Effect of Aerobic Exercise on Markers of Bone Metabolism of Overweight and Obese Patients With Chronic Kidney Disease

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art_GOMES_Effect_of_Aerobic_Exercise_on_Markers_of_Bone_2017.PDF (367.63 KB)
Citações na Scopus
38
Tipo de produção
article
Data de publicação
2017
Editora
W B SAUNDERS CO-ELSEVIER INC
DOI
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Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
GOMES, Tarcisio Santana
AOIKE, Danilo Takashi
BARIA, Flavia
CUPPARI, Lilian
Autor de Grupo de pesquisa
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Organizadores
Citação
JOURNAL OF RENAL NUTRITION, v.27, n.5, p.364-371, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: The aim of the study was to investigate the effect of aerobic exercise on markers of bone metabolism in overweight and obese nondialysis-dependent patients with chronic kidney disease. Methods: This is a post-hoc study with 39 sedentary patients (55.5 +/- 68.3 years, body mass index 31.2 +/- 64.4 kg/m(2), estimated glomerular filtration rate 26.9 +/- 6 11.7 mL/minute) who were randomly assigned to the aerobic exercise group (n = 24) or the control group (n = 15). The aerobic training (walking) was prescribed according to ventilatory threshold and was performed 3 times per week during 24 weeks. Carboxylated and undercarboxylated osteocalcin (GLA and GLU), sclerostin and tartrate-resistant acid phosphatase isoform 5b (TRAP-5b), parathyroid hormone, total alkaline phosphatase (AP), body composition, cardiorespiratory, and functional capacity tests were measured at baseline and after the follow-up. Results: At baseline, carboxylated osteocalcin (GLA) and undercarboxylated osteocalcin (GLU) were inversely correlated with estimated glomerular filtration rate (r = -0.64; r = -0.38, respectively). Both osteocalcin fragments were positively correlated with total AP (GLA: r = 0.36; GLU: r = 0.53). An inverse correlation was found between GLA and sclerostin with body fat (r = -0.36; r = -0.46, respectively). GLU was negatively correlated with markers of muscle mass (r = -0.34). TRAP-5b and sclerostin were inversely correlated with 6-minute walk test and time up and go test, respectively (r = -0.34; r = -0.35, respectively). After 24 weeks, all physical capacity parameters increased in the exercise group (P < .001). Except for total AP that increased after 24 weeks in the exercise group (P < 05), no other changes were observed in both groups in relation to the bone metabolism biomarkers investigated. Conclusion(s): In this post-hoc study, the aerobic training used did not promote relevant changes in the bone metabolism markers investigated.
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https://observatorio.fm.usp.br/handle/OPI/22183
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/16
Artigos e Materiais de Revistas Científicas - ODS/03