Detecting Neuroimaging Biomarkers for Depression: A Meta-analysis of Multivariate Pattern Recognition Studies

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art_KAMBEITZ_Detecting_Neuroimaging_Biomarkers_for_Depression_A_Metaanalysis_of_2017.PDF (1.35 MB)
Citações na Scopus
107
Tipo de produção
article
Data de publicação
2017
Editora
ELSEVIER SCIENCE INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
KAMBEITZ, Joseph
CABRAL, Carlos
SACCHET, Matthew D.
GOTLIB, Ian H.
ZAHN, Roland
WALTER, Martin
FALKAI, Peter
KOUTSOULERIS, Nikolaos
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
BIOLOGICAL PSYCHIATRY, v.82, n.5, p.330-338, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND: Multiple studies have examined functional and structural brain alteration in patients diagnosed with major depressive disorder (MDD). The introduction of multivariate statistical methods allows investigators to utilize data concerning these brain alterations to generate diagnostic models that accurately differentiate patients with MDD from healthy control subjects (HCs). However, there is substantial heterogeneity in the reported results, the methodological approaches, and the clinical characteristics of participants in these studies. METHODS: We conducted a meta-analysis of all studies using neuroimaging (volumetric measures derived from T1-weighted images, task-based functional magnetic resonance imaging [MRI], resting-state MRI, or diffusion tensor imaging) in combination with multivariate statistical methods to differentiate patients diagnosed with MDD from HCs. RESULTS: Thirty-three (k = 33) samples including 912 patients with MDD and 894 HCs were included in the metaanalysis. Across all studies, patients with MDD were separated from HCs with 77% sensitivity and 78% specificity. Classification based on resting-state MRI (85% sensitivity, 83% specificity) and on diffusion tensor imaging data (88% sensitivity, 92% specificity) outperformed classifications based on structural MRI (70% sensitivity, 71% specificity) and task-based functional MRI (74% sensitivity, 77% specificity). CONCLUSIONS: Our results demonstrate the high representational capacity of multivariate statistical methods to identify neuroimaging-based biomarkers of depression. Future studies are needed to elucidate whether multivariate neuroimaging analysis has the potential to generate clinically useful tools for the differential diagnosis of affective disorders and the prediction of both treatment response and functional outcome.
Palavras-chave
Affective disorder, Classification, Diagnosis, Prediction, Sensitivity, Specificity
URI
https://observatorio.fm.usp.br/handle/OPI/22188
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/21