Diagnosis of Oral Hairy Leukoplakia: The Importance of EBV In Situ Hybridization

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art_MARTINS_Diagnosis_of_Oral_Hairy_Leukoplakia_The_Importance_of_2017.PDF (3.1 MB)
Citações na Scopus
8
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HINDAWI LTD
Autores
MARTINS, Luana L.
ROSSETO, Jose Henrique F.
ANDRADE, Natalia Silva
FRANCO, Juliana Bertoldi
ORTEGA, Karem L.
Citação
INTERNATIONAL JOURNAL OF DENTISTRY, article ID 3457479, 6p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Oral hairy leukoplakia (OHL) is caused by the Epstein-Barr virus (EBV), which has been related to HIV infection. In situ hybridization (ISH) is the gold-standard diagnosis of OHL, but some authors believe in the possibility of performing the diagnosis based on clinical basis. The aim of this study is diagnose incipient lesions of OHL by EBV ISH of HIV-infected patients and the possible correlations with clinical characteristics of the patients. Ninety-four patients were examined and those presenting with clinical lesions compatible to OHL were submitted to biopsy prior to EBV ISH. Twenty-eight patients had lesions clinically compatible to the diagnosis of OHL, but only 20 lesions were confirmed by EBV ISH. The patients with OHL had amean age of 41.9 years and were HIV-infected for 11.2 years, on average, including CD4 count of 504.7 cells/mm 3 and log 10 viral load = 1.1. Among the quantitative variables, there was a statistically significant correlation with age only (P = 0.030). In conclusion, the presence of OHL in patients with HIV/AIDS results in changes in the epidemiological characteristics of the disease, and this fact allied with subtle clinical-morphological features makes clinical diagnosis very difficult. Therefore, EBV ISH is important for a definitive diagnosis of OHL.
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URI
https://observatorio.fm.usp.br/handle/OPI/22199
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03