Prevalence of Sjogren's syndrome in Brazilian patients infected with human T-cell lymphotropic virus

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP VALE, Daniela Assis do
OLIVEIRA, Augusto Cesar Penalva de
SOUSA, Suzana Cantanhede Orsini Machado de
ORTEGA, Karem Lopez 2017
dc.identifier.citation JOURNAL OF ORAL PATHOLOGY & MEDICINE, v.46, n.7, p.543-548, 2017
dc.identifier.issn 0904-2512
dc.description.abstract BackgroundHuman T-lymphotropic virus type I (HTLV-I) is known to be associated with neoplastic and neurodegenerative changes, and it is believed to be associated with various systemic inflammatory diseases, including Sjogren's syndrome (SS). Although HTLV-I infection is endemic in Brazil, there is no information regarding the association between HTLV-I infection and SS in the Brazilian population. The objective of this study was to determine the prevalence of SS in HTLV-I-infected individuals and the prevalence of HTLV-I infection in individuals diagnosed with SS. MethodsSerology for HTLV-I was performed in 50 patients presenting with complaints consistent with SS (the SS group). The HTLV-I group comprised 129 HTLV-I-infected patients who were screened for SS. ResultsNone of the patients in the SS group tested positive for HTLV-I. Of the 129 patients in the HTLV-I group, 46 (35.7%) had xerostomia, 18 (13.95%) had xerophthalmia, eight (6.2%) had hyposalivation, two (1.55%) showed impaired tear secretion, and one (0.77%) was positive for autoantibodies (anti-SSB). In addition, six underwent minor salivary gland biopsy, and the histopathological findings were consistent with SS. Only two (1.55%) met the diagnostic criteria for SS. ConclusionsThe prevalence of SS was found to be three times as high in HTLV-I-infected individuals as it was in those without HTLV-I infection. However, given the small number of HTLV-seropositive patients with SS, it is impossible to state that HTLV acts as an immune-activating pathogen for SS.
dc.language.iso eng
dc.publisher WILEY
dc.relation.ispartof Journal of Oral Pathology & Medicine
dc.rights restrictedAccess
dc.subject HTLV-associated myelopathy; tropical spastic paraparesis; human T-cell lymphotropic virus; Sjogren's syndrome; xerostomia
dc.subject.other salivary-glands; spastic paraparesis; i infection; htlv-i; antibodies; retrovirus; expression; serum
dc.title Prevalence of Sjogren's syndrome in Brazilian patients infected with human T-cell lymphotropic virus
dc.type article
dc.rights.holder Copyright WILEY LIM/56
dc.identifier.doi 10.1111/jop.12530
dc.identifier.pmid 27925697
dc.type.category original article
dc.type.version publishedVersion CASSEB, Jorge:IMT:DVCIENT-83 · VALE, Daniela Assis do:Univ Sao Paulo, Sch Dent, Dept Stomatol, Special Care Dent Ctr, Sao Paulo, Brazil
· OLIVEIRA, Augusto Cesar Penalva de:Inst Infect Dis Emilio Ribas, Sao Paulo, Brazil
· BUSSOLOTI FILHO, Ivo:Irmandade Santa Casa Misericordia, Dept Otorhinolaryngol, Sao Paulo, Brazil
· SOUSA, Suzana Cantanhede Orsini Machado de:Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo, Brazil
· ORTEGA, Karem Lopez:Univ Sao Paulo, Sch Dent, Dept Stomatol, Special Care Dent Ctr, Sao Paulo, Brazil 2-s2.0-85007493411 WOS:000407039200011 HOBOKEN USA
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dc.description.index MEDLINE
dc.identifier.eissn 1600-0714
hcfmusp.citation.scopus 4
hcfmusp.citation.wos 3 Brasil

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