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Title: | T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques |
Authors: | CHAMPIAT, Stephane; GARRISON, Keith E.; RAPOSO, Rui Andre Saraiva; BURWITZ, Benjamin J.; REED, Jason; TANDON, Ravi; YORK, Vanessa A.; NEWMAN, Laura P.; NIMITYONGSKUL, Francesca A.; WILSON, Nancy A.; ALMEIDA, Rafael R.; MARTIN, Jeffrey N.; DEEKS, Steven G.; ROSENBERG, Michael G.; WIZNIA, Andrew A.; SPOTTS, Gerald E.; PILCHER, Christopher D.; HECHT, Fredrick M.; OSTROWSKI, Mario A.; SACHA, Jonah B.; NIXON, Douglas F. |
Citation: | JOURNAL OF VIROLOGY, v.87, n.11, p.6073-6080, 2013 |
Abstract: | APOBEC3 proteins mediate potent antiretroviral activity by hypermutating the retroviral genome during reverse transcription. To counteract APOBEC3 and gain a replicative advantage, lentiviruses such as human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have evolved the Vif protein, which targets APOBEC3 proteins for proteasomal degradation. However, the proteasome plays a critical role in the generation of T cell peptide epitopes. Whether Vif-mediated destruction of APOBEC3 proteins leads to the generation and presentation of APOBEC3-derived T cell epitopes on the surfaces of lentivirus-infected cells remains unknown. Here, using peptides derived from multiple Vif-sensitive APOBEC3 proteins, we identified APOBEC3-specific T cell responses in both HIV-1-infected patients and SIV-infected rhesus macaques. These results raise the possibility that these T cell responses may be part of the larger antiretroviral immune response. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - LIM/60 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_ALMEIDA_T_Cells_Target_APOBEC3_Proteins_in_Human_Immunodeficiency_2013.PDF Restricted Access | publishedVersion (English) | 1.4 MB | Adobe PDF | View/Open Request a copy |
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