Effect of medium/omega-6 long chain triglyceride-based emulsion on leucocyte death and inflammatory gene expression

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art_CURY-BOAVENTURA_Effect_of_mediumomega6_long_chain_triglyceridebased_emulsion_on_2011.PDF (498.12 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2011
Editora
WILEY-BLACKWELL
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
CURY-BOAVENTURA, M. F.
GORJAO, R.
FIAMONCINI, J.
GODOY, A. B. P.
DESCHAMPHS, F. C.
CURI, R.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, v.165, n.3, p.383-392, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Lipid emulsion (LE) containing medium/omega-6 long chain triglyceride-based emulsion (MCT/omega-6 LCT LE) has been recommended in the place of omega-6 LCT-based emulsion to prevent impairment of immune function. The impact of MCT/omega-6 LCT LE on lymphocyte and neutrophil death and expression of genes related to inflammation was investigated. Seven volunteers were recruited and infusion of MCT/omega-6 LCT LE was performed for 6 h. Four volunteers received saline and no change was found. Blood samples were collected before, immediately afterwards and 18 h after LE infusion. Lymphocytes and neutrophils were studied immediately after isolation and after 24 and 48 h in culture. The following determinations were carried out: plasma-free fatty acids, triacylglycerol and cholesterol concentrations, plasma fatty acid composition, neutral lipid accumulation in lymphocytes and neutrophils, signs of lymphocyte and neutrophil death and lymphocyte expression of genes related to inflammation. MCT/omega-6 LCT LE induced lymphocyte and neutrophil death. The mechanism for MCT/omega-6 LCT LE-dependent induction of leucocyte death may involve changes in neutral lipid content and modulation of expression of genes related to cell death, proteolysis, cell signalling, inflammatory response, oxidative stress and transcription.
Palavras-chave
cell death, lymphocyte, neutrophil, MCT/omega-6 LCT-based emulsion, parenteral nutrition
URI
https://observatorio.fm.usp.br/handle/OPI/22614
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/51