Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/22618
Title: | Is anti-TNF switching in refractory Still's disease safe and effective? |
Authors: | AIKAWA, Nadia Emi; RIBEIRO, Ana Cristina de Medeiros; SAAD, Carla Goncalves Schain; PEREIRA, Rosa Maria Rodrigues; LEVY, Mauricio; SILVA, Clovis A.; BONFA, Eloisa; CARVALHO, Jozelio Freire de |
Citation: | CLINICAL RHEUMATOLOGY, v.30, n.8, p.1129-1134, 2011 |
Abstract: | Still's disease (SD) is a rare chronic inflammatory disease characterized by polyarthritis, systemic symptoms, and elevated inflammatory markers. Of note, 74 SD cases were reported with anti-tumoral necrosis factor (TNF) therapy and the experience of switching is limited to five patients. During a 3-year period, SD cases were 1.9% of 319 rheumatic patients that received anti-TNF agents in the infusion center of our University Hospital. In this manuscript, the authors add six new cases of refractory SD who had clinical and laboratory response to TNF blockers and report the outcome of switching in five of them. Partial or complete response was achieved by four of six (66.7%) patients and three of four (75%) required switching. Regarding safety, five of six (83.3%) had adverse events. Anti-TNF treatment with switching seems to be a valid approach for refractory SD patients. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/17 Artigos e Materiais de Revistas Científicas - LIM/36 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_AIKAWA_Is_antiTNF_switching_in_refractory_Stills_disease_safe_2011.PDF Restricted Access | publishedVersion (English) | 110.03 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.