Staging Alzheimer's disease progression with multimodality neuroimaging

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art_EWERS_Staging_Alzheimers_disease_progression_with_multimodality_neuroimaging_2011.PDF (1.88 MB)
Citações na Scopus
65
Tipo de produção
article
Data de publicação
2011
Editora
PERGAMON-ELSEVIER SCIENCE LTD
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
EWERS, Michael
FRISONI, Giovanni B.
TEIPEL, Stefan J.
HEINSEN, Helmut
THOMPSON, Paul M.
HAMPEL, Harald
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
PROGRESS IN NEUROBIOLOGY, v.95, n.4, Special Issue, p.535-546, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Rapid developments in medical neuroimaging have made it possible to reconstruct the trajectory of Alzheimer's disease (AD) as it spreads through the living brain. The current review focuses on the progressive signature of brain changes throughout the different stages of AD. We integrate recent findings on changes in cortical gray matter volume, white matter fiber tracts, neuropathological alterations, and brain metabolism assessed with molecular positron emission tomography (PET). Neurofibrillary tangles accumulate first in transentorhinal and cholinergic brain areas, and 4-D maps of cortical volume changes show early progressive temporo-parietal cortical thinning. Findings from diffusion tensor imaging (DTI) for assessment fiber tract integrity show cortical disconnection in corresponding brain networks. Importantly, the developmental trajectory of brain changes is not uniform and may be modulated by several factors such as onset of disease mechanisms, risk-associated and protective genes, converging comorbidity, and individual brain reserve. There is a general agreement between in vivo brain maps of cortical atrophy and amyloid pathology assessed through PET, reminiscent of post mortem histopathology studies that paved the way in the staging of AD. The association between in vivo and post mortem findings will clarify the temporal dynamics of pathophysiological alterations in the development of preclinical AD. This will be important in designing effective treatments that target specific underlying disease AD mechanisms.
Palavras-chave
Alzheimer's disease, AD, Mild cognitive impairment, MCI, Pre-dementia, Pre-clinical, Pre-symptomatic, Biological markers, Neuroimaging, Multimodal, Neuropathology, Neuroanatomy, Computational, MRI, fMRI, DTI, VBM, DBM, Tractography, Drug development, Clinical trials, CSF, Staging, Diagnosis classification, Early detection, Prediction, Biological activity, ADNI, EADNI, Regulatory authorities, FDA
URI
https://observatorio.fm.usp.br/handle/OPI/22896
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/22
Artigos e Materiais de Revistas Científicas - LIM/44