Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [F-18]Fluorodeoxyglucose-Positron-Emission Tomography Study with Partial Volume Effects Correction
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40
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article
Data de publicação
2011
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AMER SOC NEURORADIOLOGY
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AMERICAN JOURNAL OF NEURORADIOLOGY, v.32, n.3, p.560-565, 2011
Resumo
BACKGROUND AND PURPOSE: Functional brain variability has been scarcely investigated in cognitively healthy elderly subjects, and it is currently debated whether previous findings of regional metabolic variability are artifacts associated with brain atrophy. The primary purpose of this study was to test whether there is regional cerebral age-related hypometabolism specifically in later stages of life. MATERIALS AND METHODS: MR imaging and FDG-PET data were acquired from 55 cognitively healthy elderly subjects, and voxel-based linear correlations between age and GM volume or regional cerebral metabolism were conducted by using SPM5 in images with and without correction for PVE. To investigate sex-specific differences in the pattern of brain aging, we repeated the above voxelwise calculations after dividing our sample by sex. RESULTS: Our analysis revealed 2 large clusters of age-related metabolic decrease in the overall sample, 1 in the left orbitofrontal cortex and the other in the right temporolimbic region, encompassing the hippocampus, the parahippocampal gyrus, and the amygdala. The division of our sample by sex revealed significant sex-specific age-related metabolic decrease in the left temporolimbic region of men and in the left dorsolateral frontal cortex of women. When we applied atrophy correction to our PET data, none of the above-mentioned correlations remained significant. CONCLUSIONS: Our findings suggest that age-related functional brain variability in cognitively healthy elderly individuals is largely secondary to the degree of regional brain atrophy, and the findings provide support to the notion that appropriate PVE correction is a key tool in neuroimaging investigations.
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Referências
- American Psychiatric Association, 1994, DIAGN STAT MAN MENT
- Samuraki M, 2007, EUR J NUCL MED MOL I, V34, P1658, DOI 10.1007/s00259-007-0454-x
- Quarantelli M, 2004, J NUCL MED, V45, P192
- Petit-Taboue MC, 1998, NEUROIMAGE, V7, P176, DOI 10.1006/nimg.1997.0318
- Mosconi L, 2008, NEUROBIOL AGING, V29, P676, DOI 10.1016/j.neurobiolaging.2006.12.008
- Wilson PWF, 1998, CIRCULATION, V97, P1837
- Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
- Kochunov P, 2009, NEUROIMAGE, V45, P17, DOI 10.1016/j.neuroimage.2008.11.010
- Yassa MA, 2009, NEUROIMAGE, V44, P319, DOI 10.1016/j.neuroimage.2008.09.016
- Klein A, 2009, NEUROIMAGE, V46, P786, DOI 10.1016/j.neuroimage.2008.12.037
- Taki Y, 2004, NEUROBIOL AGING, V25, P455, DOI 10.1016/j.neurobiolaging.2003.09.002
- Kalpouzos G, 2009, NEUROBIOL AGING, V30, P112, DOI 10.1016/j.neurobiolaging.2007.05.019
- Aston JAD, 2002, J CEREBR BLOOD F MET, V22, P1019
- Moeller JR, 1996, J CEREBR BLOOD F MET, V16, P385
- Fouquet M, 2009, BRAIN, V132, P2058, DOI 10.1093/brain/awp132
- MAZZIOTTA JC, 1995, NEUROIMAGE, V2, P89, DOI 10.1006/nimg.1995.1012
- Mosconi L, 2006, J NUCL MED, V47, P1778
- Fujimoto T, 2008, PSYCHIAT RES-NEUROIM, V164, P58, DOI 10.1016/j.pscychresns.2006.12.014
- Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
- Yanase D, 2005, EUR J NUCL MED MOL I, V32, P794, DOI 10.1007/s00259-005-1767-2
- Copeland JRM, 2002, INT J GERIATR PSYCH, V17, P729, DOI 10.1002/gps.667
- Ibanez V, 1998, NEUROLOGY, V50, P1585
- Scazufca M, 2008, INT PSYCHOGERIATR, V20, P394, DOI 10.1017/S1041610207005625
- Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
- Townsend DW, 2008, SEMIN NUCL MED, V38, P152, DOI 10.1053/j.semnuclmed.2008.01.003
- Small GW, 2008, LANCET NEUROL, V7, P161, DOI 10.1016/S1474-4422(08)70019-X
- Mevel K, 2007, NEUROIMAGE, V37, P18, DOI 10.1016/j.neuroimage.2007.04.048
- Curiati PK, 2009, AM J NEURORADIOL, V30, P1850, DOI 10.3174/ajnr.A1727
- Meltzer CC, 1996, NEUROLOGY, V47, P454
- Hall KS, 2000, INT J GERIATR PSYCH, V15, P521, DOI 10.1002/1099-1166(200006)15:6<521::AID-GPS182>3.0.CO;2-F
- Scazufca M, 2008, INT J EPIDEMIOL, V37, P721, DOI 10.1093/ije/dym154
- Raz N, 2005, CEREB CORTEX, V15, P1676, DOI 10.1093/cercor/bhi044
- Kennedy KM, 2009, NEUROBIOL AGING, V30, P1657, DOI 10.1016/j.neurobiolaging.2007.12.020
- Meltzer CC, 2000, J NUCL MED, V41, P1842
- Ashburner J, 2009, MAGN RESON IMAGING, V27, P1163, DOI 10.1016/j.mri.2009.01.006
- DELEON MJ, 1984, J COMPUT ASSIST TOMO, V8, P88, DOI 10.1097/00004728-198402000-00017
- DELEON MJ, 1987, NEUROBIOL AGING, V8, P319, DOI 10.1016/0197-4580(87)90070-4
- Drzezga A, 2008, NEUROIMAGE, V39, P619, DOI 10.1016/j.neuroimage.2007.09.020
- DUARA R, 1983, BRAIN, V106, P761, DOI 10.1093/brain/106.3.761
- Friston KJ, 1995, HUMAN BRAIN MAPPING, V2, P189, DOI 10.1002/HBM.460020402
- Ganguli M, 1996, Int Psychogeriatr, V8, P507, DOI 10.1017/S1041610296002852
- HAMILTON M, 1967, BRIT J SOC CLIN PSYC, V6, P278
- Inoue K, 2005, ANN NUCL MED, V19, P283, DOI 10.1007/BF02984620
- Prince M, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-165
- RAPOPORT SI, 1984, PSYCHOPHARMACOL BULL, V20, P466
- Reiman EM, 2010, NEUROIMAGE, V49, P169, DOI 10.1016/j.neuroimage.2009.07.025
- Rimajova M, 2008, J ALZHEIMERS DIS, V13, P137
- SCHLAGETER NL, 1987, J NEUROL NEUROSUR PS, V50, P779, DOI 10.1136/jnnp.50.6.779
- TALAIRACH J, 1998, COPLANNER STEREOTAXI
- Willis MW, 2002, PSYCHIAT RES-NEUROIM, V114, P23, DOI 10.1016/S0925-4927(01)00126-3
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