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https://observatorio.fm.usp.br/handle/OPI/22914| Title: | HPV-58 Molecular Variants Exhibit Different Transcriptional Activity |
| Authors: | RAIOL, Taina; AMORIM, Regina Maria Santos de; GALANTE, Pedro; MARTINS, Claudia Renata Fernandes; VILLA, Luisa Lina; SICHERO, Laura |
| Citation: | INTERVIROLOGY, v.54, n.3, p.146-150, 2011 |
| Abstract: | Early promoter activity of HPV-58 molecular variants isolated from high-grade cervical lesions in Brazil was compared. Luciferase reporter assays were conducted in C33 cells transfected with the complete long control region of 3 molecular variants of HPV-58 as well as HPV-58, -18 or -16 prototypes. The HPV-58 prototype and Bsb-329 and Bsb-367 variants showed a promoter activity similar to that of HPV-16, but lower than that of Bsb-295 and HPV-18. The introduction of the Bsb-295 7788 mutation into the HPV-58 prototype resulted in the enhancement of transcription closer to Bsb-295 and HPV-18. These results could impact the expression of E6 and E7 viral oncogenes. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR |
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|---|---|---|---|---|
| art_RAIOL_HPV58_Molecular_Variants_Exhibit_Different_Transcriptional_Activity_2011.PDF Restricted Access | publishedVersion (English) | 134.77 kB | Adobe PDF | View/Open Request a copy |
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