A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author CHEN, Dan
TRUONG, Therese
GABORIEAU, Valerie
BYRNES, Graham
CHABRIER, Amelie
CHUANG, Shu-chun
OLSHAN, Andrew F.
WEISSLER, Mark C.
LUO, Jingchun
ROMKES, Marjorie
BUCH, Shama
NUKUI, Tomoko
FRANCESCHI, Silvia
HERRERO, Rolando
TALAMINI, Renato
KELSEY, Karl T.
CHRISTENSEN, Brock
MCCLEAN, Michael D.
LACKO, Martin
MANNI, Johannes J.
PETERS, Wilbert H. M.
LUBINSKI, Jan
TRUBICKA, Joanna
LENER, Marcin
MUSCAT, Joshua E.
LAZARUS, Philip
WEI, Qingyi
STURGIS, Erich M.
ZHANG, Zuo-Feng
CHANG, Shen-Chih
WANG, Renyi
SCHWARTZ, Stephen M.
CHEN, Chu
BENHAMOU, Simone
LAGIOU, Pagona
HOLCATOV, Ivana
RICHIARDI, Lorenzo
KJAERHEIM, Kristina
AGUDO, Antonio
CASTELLSAGUE, Xavier
MACFARLANE, Tatiana V.
BARZAN, Luigi
CANOVA, Cristina
THAKKER, Nalin S.
CONWAY, David I.
ZNAOR, Ariana
HEALY, Claire M.
AHRENS, Wolfgang
ZARIDZE, David
SZESZENIA-DABROWSKA, Neonila
LISSOWSKA, Jolanta
FABIANOVA, Eleonora
BUCUR, Alexandru
BENCKO, Vladimir
FORETOVA, Lenka
JANOUT, Vladimir
CURADO, Maria Paula
KOIFMAN, Sergio
MENEZES, Ana
WUENSCH-FILHO, Victor
ELUF-NETO, Jose FMUSP-HC
FERNANDEZ, Leticia
BOCCIA, Stefania
HASHIBE, Mia
HAYES, Richard B.
BOFFETTA, Paolo
BRENNAN, Paul
MCKAY, James D.
dc.date.issued 2011
dc.identifier.citation CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, v.20, n.4, p.658-664, 2011
dc.identifier.issn 1055-9965
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23346
dc.description.abstract Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P-het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 x 10(-6)) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P-het = 6 x 10(-4)). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P-het = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations. Cancer Epidemiol Biomarkers Prev; 20(4); 658-64. (C) 2011 AACR.
dc.description.sponsorship · U.S. National Cancer Institute [R01 CA092039 05/05S1]
· National Institute of Dental and Craniofacial Research [1R03DE020116-01]
dc.language.iso eng
dc.publisher AMER ASSOC CANCER RESEARCH
dc.relation.ispartof Cancer Epidemiology Biomarkers & Prevention
dc.rights restrictedAccess
dc.subject.other nicotinic acetylcholine-receptors; lung-cancer; susceptibility locus; risk; dependence; expression; genes; age
dc.title A Sex-Specific Association between a 15q25 Variant and Upper Aerodigestive Tract Cancers
dc.type article
dc.rights.holder Copyright AMER ASSOC CANCER RESEARCH
dc.description.group LIM/38
dc.identifier.doi 10.1158/1055-9965.EPI-10-1008
dc.identifier.pmid 21335511
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author ELUF-NETO, Jose:FM:MPR
hcfmusp.author.external · CHEN, Dan:Int Agcy Res Canc, F-69372 Lyon 08, France
· TRUONG, Therese:Int Agcy Res Canc, F-69372 Lyon 08, France
· GABORIEAU, Valerie:Int Agcy Res Canc, F-69372 Lyon 08, France
· BYRNES, Graham:Int Agcy Res Canc, F-69372 Lyon 08, France
· CHABRIER, Amelie:Int Agcy Res Canc, F-69372 Lyon 08, France
· CHUANG, Shu-chun:Int Agcy Res Canc, F-69372 Lyon 08, France
· OLSHAN, Andrew F.:Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA; Univ N Carolina, Sch Med, Chapel Hill, NC USA
· LUO, Jingchun:Univ N Carolina, Sch Med, Chapel Hill, NC USA
· ROMKES, Marjorie:Univ Pittsburgh, Pittsburgh, PA USA
· BUCH, Shama:Univ Pittsburgh, Pittsburgh, PA USA
· NUKUI, Tomoko:Univ Pittsburgh, Pittsburgh, PA USA
· FRANCESCHI, Silvia:Int Agcy Res Canc, F-69372 Lyon 08, France
· HERRERO, Rolando:Inst Invest Epidemiol, San Jose, Costa Rica
· TALAMINI, Renato:IRCCS, Natl Canc Inst, Aviano, Italy
· KELSEY, Karl T.:Brown Univ, Providence, RI 02912 USA
· CHRISTENSEN, Brock:Brown Univ, Providence, RI 02912 USA
· MCCLEAN, Michael D.:Boston Univ, Sch Publ Hlth, Boston, MA USA
· LACKO, Martin:Maastricht Univ, Dept Otorhinolaryngol & Head & Neck Surg, Maastricht, Netherlands
· MANNI, Johannes J.:Maastricht Univ, Dept Otorhinolaryngol & Head & Neck Surg, Maastricht, Netherlands
· PETERS, Wilbert H. M.:Radboud Univ Nijmegen, Dept Gastroenterol, NL-6525 ED Nijmegen, Netherlands
· LUBINSKI, Jan:Pomeranian Med Univ, Dept Genet & Pathomorphol, Szczecin, Poland
· TRUBICKA, Joanna:Pomeranian Med Univ, Dept Genet & Pathomorphol, Szczecin, Poland
· LENER, Marcin:Pomeranian Med Univ, Dept Genet & Pathomorphol, Szczecin, Poland
· MUSCAT, Joshua E.:Penn State Coll Med, Hershey, PA USA
· LAZARUS, Philip:Penn State Coll Med, Hershey, PA USA
· WEI, Qingyi:Univ Texas MD Anderson Canc Site, Houston, TX USA
· STURGIS, Erich M.:Univ Texas MD Anderson Canc Site, Houston, TX USA
· ZHANG, Zuo-Feng:Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
· CHANG, Shen-Chih:Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
· WANG, Renyi:Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
· SCHWARTZ, Stephen M.:Fred Hutchinson Canc Res Site, Seattle, WA USA
· CHEN, Chu:Fred Hutchinson Canc Res Site, Seattle, WA USA
· BENHAMOU, Simone:INSERM, U946, Paris, France; Inst Gustave Roussy, CNRS, Villejuif, France
· LAGIOU, Pagona:Univ Athens, Sch Med, GR-11527 Athens, Greece
· HOLCATOV, Ivana:Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic
· RICHIARDI, Lorenzo:Univ Turin, Unit Canc Epidemiol, Turin, Italy
· KJAERHEIM, Kristina:Canc Registry Norway, Oslo, Norway
· AGUDO, Antonio:ICO, Barcelona, Spain
· CASTELLSAGUE, Xavier:ICO, Barcelona, Spain
· MACFARLANE, Tatiana V.:Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland
· BARZAN, Luigi:Gen Hosp Pordenone, Pordenone, Italy
· CANOVA, Cristina:Univ Padua, Dept Environm Med & Publ Hlth, Padua, Italy; Univ London Imperial Coll Sci Technol & Med, Sch Med NHLI, MRC HPA Ctr Environm & Hlth, Dept Resp Epidemiol & Publ Hlth, London, England
· THAKKER, Nalin S.:Univ Manchester, Sch Dent, Manchester, Lancs, England
· CONWAY, David I.:Univ Glasgow, Sch Dent, Glasgow, Lanark, Scotland
· ZNAOR, Ariana:Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia
· HEALY, Claire M.:Trinity Coll Dublin, Sch Dent Sci, Dublin, Ireland
· AHRENS, Wolfgang:Univ Bremen, Bremen Inst Prevent Res & Social Med BIPS, Bremen, Germany
· ZARIDZE, David:Inst Carcinogenesis, Moscow, Russia
· SZESZENIA-DABROWSKA, Neonila:Inst Occupat Med, Dept Epidemiol, Lodz, Poland
· LISSOWSKA, Jolanta:M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland; Inst Oncol, Warsaw, Poland
· FABIANOVA, Eleonora:Reg Author Publ Hlth, Banska Bystrica, Slovakia
· BUCUR, Alexandru:Inst Publ Hlth, Bucharest, Romania
· BENCKO, Vladimir:Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic
· FORETOVA, Lenka:Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
· JANOUT, Vladimir:Palacky Univ, CR-77147 Olomouc, Czech Republic
· CURADO, Maria Paula:Int Agcy Res Canc, F-69372 Lyon 08, France
· KOIFMAN, Sergio:Escola Nacl Suade Publ, Rio De Janeiro, Brazil
· MENEZES, Ana:Univ Fed Pelotas, Pelotas, Brazil
· WUENSCH-FILHO, Victor:Univ Sao Paulo, Sao Paulo, Brazil
· FERNANDEZ, Leticia:Inst Oncol & Radiobiol, Havana, Cuba
· BOCCIA, Stefania:Univ Cattolica Sacro Cuore, Inst Hyg, I-20123 Milan, Italy; IRCCS San Raffaele Pisana, Rome, Italy
· HASHIBE, Mia:Int Agcy Res Canc, F-69372 Lyon 08, France; Univ Utah, Sch Med, Salt Lake City, UT USA
· HAYES, Richard B.:NYU, Langone Med Ctr New York, New York, NY USA
· BOFFETTA, Paolo:Int Agcy Res Canc, F-69372 Lyon 08, France; Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA; Int Prevent Res Inst, Lyon, France
· BRENNAN, Paul:Int Agcy Res Canc, F-69372 Lyon 08, France
· MCKAY, James D.:Int Agcy Res Canc, F-69372 Lyon 08, France
hcfmusp.origem.id WOS:000288993000016
hcfmusp.origem.id 2-s2.0-79955799786
hcfmusp.publisher.city PHILADELPHIA
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1538-7755
hcfmusp.citation.scopus 11
hcfmusp.citation.wos 11
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Espanha
hcfmusp.affiliation.country Noruega
hcfmusp.affiliation.country República Tcheca
hcfmusp.affiliation.country Grécia
hcfmusp.affiliation.country Polônia
hcfmusp.affiliation.country Holanda
hcfmusp.affiliation.country Itália
hcfmusp.affiliation.country Costa Rica
hcfmusp.affiliation.country Estados Unidos
hcfmusp.affiliation.country França
hcfmusp.affiliation.country Alemanha
hcfmusp.affiliation.country Irlanda
hcfmusp.affiliation.country Croácia
hcfmusp.affiliation.country Cuba
hcfmusp.affiliation.country Romênia
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