Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis

Imagem de Miniatura
Arquivos
art_GIGANTE_Morphometric_postmortem_studies_in_bipolar_disorder_possible_association_2011.PDF (303.62 KB)
Citações na Scopus
75
Tipo de produção
article
Data de publicação
2011
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
YOUNG, Lionel Trevor
YATHAM, Lakshmi N.
ANDREAZZA, Ana Cristina
GRINBERG, Lea Tenenholz
HEINSEN, Helmut
Citação
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, v.14, n.8, p.1075-1089, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Despite extensive research in the last decades, the pathophysiology of bipolar disorder (BD) remains unclear. Access to post-mortem brain tissue of subjects who had BD offers an opportunity to investigate neurobiology and this approach has led to some progress, particularly, due to the availability of more sophisticated molecular and cellular biological methodologies and well characterized brain collections over the past decade. Here we review the findings of morphometric post-mortem studies in BD and interpret them in the context of a potential physiopathological mechanism involving oxidative stress and apoptosis. A review of the literature was conducted to identify post-mortem studies that investigated cellular changes such as number, density and size of neurons and glia, in brains of subjects with BD. We found decreased density of neurons and glia and decreased size of neurons in frontal and subcortical areas of the brain. Based on recent studies that found evidence of increased apoptosis and oxidative stress in BD, we hypothesize that the cell abnormalities described are due to an increase in the apoptotic process that can be triggered, through its intrinsic pathway, by the existence of an exacerbated production of reactive oxygen species and oxidative damage in the disease.
Palavras-chave
Apoptosis, bipolar disorder, neuropathology, oxidative stress
URI
https://observatorio.fm.usp.br/handle/OPI/23385
Referências
  1. ABDALLA DSP, 1986, CLIN CHEM, V32, P805
  2. Aliyazicioğlu Rezzan, 2007, Tohoku J Exp Med, V213, P79, DOI 10.1620/tjem.213.79
  3. Andreazza Ana Cristina, 2009, J Psychiatry Neurosci, V34, P263
  4. Rao JS, 2010, MOL PSYCHIATR, V15, P384, DOI 10.1038/mp.2009.47
  5. Buttner N, 2007, SCHIZOPHR RES, V93, P33, DOI 10.1016/j.schres.2007.01.030
  6. Arnone D, 2009, BRIT J PSYCHIAT, V195, P194, DOI 10.1192/bjp.bp.108.059717
  7. Kaur S, 2005, AM J PSYCHIAT, V162, P1637, DOI 10.1176/appi.ajp.162.9.1637
  8. O'Donovan MC, 2009, HUM GENET, V126, P3, DOI 10.1007/s00439-009-0703-0
  9. Sassi RB, 2005, AM J PSYCHIAT, V162, P2109, DOI 10.1176/appi.ajp.162.11.2109
  10. Beasley CL, 2002, BIOL PSYCHIAT, V52, P708, DOI 10.1016/S0006-3223(02)01360-4
  11. Brambilla P, 2003, MOL PSYCHIATR, V8, P721, DOI 10.1038/sj.mp.4001362
  12. Ott M, 2007, APOPTOSIS, V12, P913, DOI 10.1007/s10495-007-0756-2
  13. Miguel-Hidalgo JJ, 2002, BIOL PSYCHIAT, V52, P1121, DOI 10.1016/S0006-3223(02)01439-7
  14. Ongur D, 1998, P NATL ACAD SCI USA, V95, P13290, DOI 10.1073/pnas.95.22.13290
  15. Benes FM, 1998, BIOL PSYCHIAT, V44, P88, DOI 10.1016/S0006-3223(98)00138-3
  16. Benes FM, 2001, BIOL PSYCHIAT, V50, P395, DOI 10.1016/S0006-3223(01)01084-8
  17. Berretta S, 2007, BIOL PSYCHIAT, V62, P884, DOI 10.1016/j.biopsych.2007.04.023
  18. Galluzzi L, 2009, NAT REV NEUROSCI, V10, P481, DOI 10.1038/nrn2665
  19. Wang JF, 2009, BIPOLAR DISORD, V11, P523, DOI 10.1111/j.1399-5618.2009.00717.x
  20. Bowley MP, 2002, BIOL PSYCHIAT, V52, P404, DOI 10.1016/S0006-3223(02)01404-X
  21. Vostrikov VM, 2007, SCHIZOPHR RES, V94, P273, DOI 10.1016/j.schres.2007.01.014
  22. Altshuler L, 2008, BIPOLAR DISORD, V10, P708, DOI 10.1111/j.1399-5618.2008.00617.x
  23. Harrison PJ, 2002, BRAIN, V125, P1428, DOI 10.1093/brain/awf149
  24. Andreazza AC, 2010, ARCH GEN PSYCHIAT, V67, P360, DOI 10.1001/archgenpsychiatry.2010.22
  25. Chana G, 2003, BIOL PSYCHIAT, V53, P1086, DOI 10.1016/S0006-3223(03)00114-8
  26. Uranova NA, 2004, SCHIZOPHR RES, V67, P269, DOI 10.1016/S0920-9964(03)00181-6
  27. Gergerlioglu HS, 2007, PROG NEURO-PSYCHOPH, V31, P697, DOI 10.1016/j.pnpbp.2006.12.020
  28. Woo TUW, 2004, ARCH GEN PSYCHIAT, V61, P649, DOI 10.1001/archpsyc.61.7.649
  29. Andreazza AC, 2008, J AFFECT DISORDERS, V111, P135, DOI 10.1016/j.jad.2008.04.013
  30. Bielau H, 2005, EUR ARCH PSY CLIN N, V255, P401, DOI 10.1007/s00406-005-0581-y
  31. Machado-Vieira R, 2007, NEUROSCI LETT, V421, P33, DOI 10.1016/j.neulet.2007.05.016
  32. Kugaya A, 2005, CNS SPECTRUMS, V10, P808
  33. Cotter D, 2002, CEREB CORTEX, V12, P386, DOI 10.1093/cercor/12.4.386
  34. Young KA, 2004, AM J PSYCHIAT, V161, P1270, DOI 10.1176/appi.ajp.161.7.1270
  35. Muller MB, 2001, EUR J NEUROSCI, V14, P1603, DOI 10.1046/j.0953-816x.2001.01784.x
  36. Kuloglu M, 2002, CELL BIOCHEM FUNCT, V20, P171, DOI 10.1002/cbf.940
  37. Sakai T, 2008, NEUROPATHOLOGY, V28, P143, DOI 10.1111/j.1440-1789.2007.00867.x
  38. Palomino A, 2006, SCHIZOPHR RES, V86, P321, DOI 10.1016/j.schres.2006.05.028
  39. Selek S, 2008, J AFFECT DISORDERS, V107, P89, DOI 10.1016/j.jad.2007.08.006
  40. Rajkowska G, 2005, BIOL PSYCHIAT, V58, P297, DOI 10.1016/j.biopsych.2005.04.013
  41. Deicken RF, 2003, AM J PSYCHIAT, V160, P873, DOI 10.1176/appi.ajp.160.5.873
  42. Bezchlibnyk YB, 2007, J PSYCHIATR NEUROSCI, V32, P203
  43. Bertolino A, 2003, BIOL PSYCHIAT, V53, P906, DOI 10.1016/S0006-3223(02)01911-X
  44. Konradi C, 2004, ARCH GEN PSYCHIAT, V61, P300, DOI 10.1001/archpsyc.61.3.300
  45. Cotter D, 2002, BIOL PSYCHIAT, V51, P377, DOI 10.1016/S0006-3223(01)01243-4
  46. Schloesser RJ, 2008, NEUROPSYCHOPHARMACOL, V33, P110, DOI 10.1038/sj.npp.1301575
  47. Nonaka S, 1998, P NATL ACAD SCI USA, V95, P2642, DOI 10.1073/pnas.95.5.2642
  48. Sun XJ, 2006, J PSYCHIATR NEUROSCI, V31, P189
  49. Benes FM, 2006, MOL PSYCHIATR, V11, P241, DOI 10.1038/sj.mp.4001758
  50. Cotter D, 2001, ARCH GEN PSYCHIAT, V58, P545, DOI 10.1001/archpsyc.58.6.545
  51. Andreazza AC, 2007, J PSYCHIATR RES, V41, P523, DOI 10.1016/j.jpsychires.2006.07.013
  52. Rutten BPF, 2009, SCHIZOPHRENIA BULL, V35, P1045, DOI 10.1093/schbul/sbp104
  53. Orrenius S, 2007, DRUG METAB REV, V39, P443, DOI 10.1080/03602530701468516
  54. Frazier JA, 2005, AM J PSYCHIAT, V162, P1256, DOI 10.1176/appi.ajp.162.7.1256
  55. Benes FM, 2001, TRENDS NEUROSCI, V24, P11, DOI 10.1016/S0166-2236(00)01660-X
  56. Hamidi M, 2004, BIOL PSYCHIAT, V55, P563, DOI 10.1016/j.biopsych.2003.11.006
  57. Bei E, 2009, PSYCHONEUROENDOCRINO, V34, P1162, DOI 10.1016/j.psyneuen.2009.03.002
  58. Ranjekar PK, 2003, PSYCHIAT RES, V121, P109, DOI 10.1016/S0165-1781(03)00220-8
  59. Yatham LN, 2005, BIPOLAR DISORD, V7, P13, DOI 10.1111/j.1399-5618.2005.00211.x
  60. Kato T, 2008, TRENDS NEUROSCI, V31, P495, DOI 10.1016/j.tins.2008.07.007
  61. Kato T, 2006, DRUG NEWS PERSPECT, V19, P597, DOI 10.1358/dnp.2006.19.10.1068006
  62. Rowe Michael K., 2004, Expert Reviews in Molecular Medicine, V6, P1, DOI 10.1017/S1462399404008385
  63. Schmitz C, 2005, NEUROSCIENCE, V130, P813, DOI 10.1016/j.neuroscience.2004.08.050
  64. Bouras C, 2001, ACTA NEUROPATHOL, V102, P373
  65. Daban C, 2005, PSYCHIAT CLIN N AM, V28, P469, DOI 10.1016/j.psc.2005.01.005
  66. Stork C, 2005, MOL PSYCHIATR, V10, P900, DOI 10.1038/sj.mp.4001711
  67. Law AJ, 2003, J PSYCHIAT RES, V37, P487, DOI 10.1016/S0022-3956(03)00075-X
  68. Pfeifer JC, 2008, J AM ACAD CHILD PSY, V47, P1289, DOI 10.1097/CHI.0b013e318185d299
  69. Che Y, 2010, J PSYCHIATR NEUROSCI, V35, P296, DOI 10.1503/jpn.090083
  70. Chen G, 1999, J NEUROCHEM, V72, P879, DOI 10.1046/j.1471-4159.1999.720879.x
  71. Moore GJ, 2009, J CLIN PSYCHIAT, V70, P699, DOI 10.4088/JCP.07m03745
  72. Kim HW, 2010, NEUROBIOL DIS, V37, P596, DOI 10.1016/j.nbd.2009.11.010
  73. Yucel K, 2007, PSYCHOPHARMACOLOGY, V195, P357, DOI 10.1007/s00213-007-0906-9
  74. Geuna S, 2000, J COMP NEUROL, V427, P333
  75. Moffett JR, 2007, PROG NEUROBIOL, V81, P89, DOI 10.1016/j.pneurobio.2006.12.003
  76. Uranova N, 2001, BRAIN RES BULL, V55, P597, DOI 10.1016/S0361-9230(01)00528-7
  77. Andreazza AC, 2007, PSYCHIAT RES, V153, P27, DOI 10.1016/j.psychres.2006.03.025
  78. Rajkowska G, 2001, BIOL PSYCHIAT, V49, P741, DOI 10.1016/S0006-3223(01)01080-0
  79. Yucel K, 2008, NEUROPSYCHOPHARMACOL, V33, P361, DOI 10.1038/sj.npp.1301405
  80. Kunz M, 2008, PROG NEURO-PSYCHOPH, V32, P1677, DOI 10.1016/j.pnpbp.2008.07.001
  81. Byne W, 2008, SCHIZOPHR RES, V106, P172, DOI 10.1016/j.schres.2008.08.023
  82. Wang JF, 2003, NEUROSCIENCE, V116, P485, DOI 10.1016/S0306-4522(02)00655-3
  83. Kroemer G, 2009, CELL DEATH DIFFER, V16, P3, DOI 10.1038/cdd.2008.150
  84. Drevets WC, 1997, NATURE, V386, P824, DOI 10.1038/386824a0
  85. Beasley CL, 2002, MOL PSYCHIATR, V7, P564, DOI 10.1038/sj.mp.4001038
  86. Rajkowska G, 2002, BIPOLAR DISORD, V4, P105, DOI 10.1034/j.1399-5618.2002.01149.x
  87. Fountoulakis KN, 2008, BRAIN RES REV, V59, P9, DOI 10.1016/j.brainresrev.2008.04.005
  88. Winsberg ME, 2000, BIOL PSYCHIAT, V47, P475, DOI 10.1016/S0006-3223(99)00183-3
  89. Grinberg LT, 2009, J NEUROL SCI, V283, P2, DOI 10.1016/j.jns.2009.02.327
  90. Atmaca M, 2006, PROG NEURO-PSYCHOPH, V30, P1235, DOI 10.1016/j.pnpbp.2006.03.032
  91. Brooks JO, 2009, J PSYCHIATR RES, V43, P497, DOI 10.1016/j.jpsychires.2008.08.001
  92. Burruss JW, 2000, RADIOLOGY, V214, P227
  93. Chana G, 2008, SCHIZOPHR RES, V102, P344, DOI 10.1016/j.schres.2008.04.021
  94. EVERALL IP, 2002, POSTMORTEM BRAIN PSY, P21
  95. GRUNDT IK, 1994, TOXICOL IN VITRO, V8, P1015, DOI 10.1016/0887-2333(94)90236-4
  96. HAYES TL, 1991, J COMP NEUROL, V303, P584, DOI 10.1002/cne.903030406
  97. Hercher Christa, 2009, J Psychiatry Neurosci, V34, P281
  98. Kauer-Sant'Anna M, 2009, INT J NEUROPSYCHOPH, V12, P447, DOI 10.1017/S1461145708009310
  99. Keener Matthew T, 2007, Curr Psychiatry Rep, V9, P512, DOI 10.1007/s11920-007-0070-2
  100. Kodamo M, 2004, BIOL PSYCHIAT, V56, P570, DOI 10.1016/j.biopsych.2004.07.008
  101. Koo MS, 2008, ARCH GEN PSYCHIAT, V65, P746, DOI 10.1001/archpsyc.65.7.746
  102. Liu LS, 2007, CELL MOL NEUROBIOL, V27, P351, DOI 10.1007/s10571-006-9128-7
  103. Miguel-Hidalgo JJ, 2003, J PSYCHIAT RES, V37, P411, DOI 10.1016/S0022-3956(03)00049-9
  104. Molina V, 2007, EUR PSYCHIAT, V22, P505, DOI 10.1016/j.eurpsy.2007.07.006
  105. Olvera RL, 2007, J CHILD ADOL PSYCHOP, V17, P461, DOI 10.1089/cap.2007.0102
  106. Omata N, 2008, BIPOLAR DISORD, V10, P360, DOI 10.1111/j.1399-5618.2007.00521.x
  107. Sanacora G, 2008, J CLIN PSYCHIAT, V69, P22
  108. Scherk H, 2008, ACTA PSYCHIAT SCAND, V117, P283, DOI 10.1111/j.1600-0447.2007.01142.x
  109. Selemon LD, 1999, BIOL PSYCHIAT, V46, P161, DOI 10.1016/S0006-3223(99)00113-4
  110. Teipel S.J., 2008, EUR J NUCL MED MO S1, V35, P58, DOI 10.1007/s00259-007-0703-z
  111. Wang JF, 2007, CAN J PSYCHIAT, V52, P753
  112. Yatham LN, 2009, INT J NEUROPSYCHOPH, V12, P137, DOI 10.1017/S1461145708009449
  113. Yeste M, 2007, J NEURAL TRANSM, V114, P405, DOI 10.1007/s00702-006-0557-8
  114. Young KA, 2007, BIOL PSYCHIAT, V61, P813, DOI 10.1016/j.biopsych.2006.08.047
  115. Young LT, 2001, J PSYCHIATR NEUROSCI, V26, pS17
  116. Young LT, 2002, J PSYCHIATR NEUROSCI, V27, P260
  117. Zhong J, 2006, BIOCHEM BIOPH RES CO, V350, P905, DOI 10.1016/j.bbrc.2006.09.138

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/21