Revisiting Langerhans cells in paracoccidioidomycosis: expression of CD207/langerin in human cutaneous and mucosal lesions

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author PAGLIARI, Carla FMUSP-HC
FERNANDES, Elaine Raniero FMUSP-HC
SILVA, Wellington Luiz Ferreira da FMUSP-HC
SILVA, Aline Alves de Lima
STEGUN, Felipe Weisshaupt FMUSP-HC
DUARTE, Maria Irma Seixas FMUSP-HC
SOTTO, Mirian Nacagami FMUSP-HC
dc.date.issued 2011
dc.identifier.citation MICROBES AND INFECTION, v.13, n.12-13, p.1012-1017, 2011
dc.identifier.issn 1286-4579
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23458
dc.description.abstract Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil [2008/09355-8]
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE BV
dc.relation.ispartof Microbes and Infection
dc.rights restrictedAccess
dc.subject Paracoccidioidomycosis; Langerin; Immune response
dc.subject.other langerin(+) dendritic cells; c-type lectin; birbeck granules; skin-lesions; t-cells; immunity; cd1a
dc.title Revisiting Langerhans cells in paracoccidioidomycosis: expression of CD207/langerin in human cutaneous and mucosal lesions
dc.type article
dc.rights.holder Copyright ELSEVIER SCIENCE BV
dc.description.group LIM/06
dc.description.group LIM/53
dc.identifier.doi 10.1016/j.micinf.2011.06.006
dc.identifier.pmid 21757025
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author PAGLIARI, Carla:FM:MPT
hcfmusp.author FERNANDES, Elaine Raniero:HC:ICHC
hcfmusp.author SILVA, Wellington Luiz Ferreira da:HC:LIM/06
hcfmusp.author STEGUN, Felipe Weisshaupt:HC:FFM
hcfmusp.author DUARTE, Maria Irma Seixas:FM:MPT
hcfmusp.author SOTTO, Mirian Nacagami:FM:MDT
hcfmusp.author.external · SILVA, Aline Alves de Lima:Univ Sao Paulo, Fac Med, Dept Patol, BR-01246903 Sao Paulo, Brazil
hcfmusp.origem.id WOS:000296216000007
hcfmusp.origem.id 2-s2.0-80053384019
hcfmusp.publisher.city AMSTERDAM
hcfmusp.publisher.country NETHERLANDS
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dc.description.index MEDLINE
hcfmusp.citation.scopus 2
hcfmusp.citation.wos 2
hcfmusp.affiliation.country Brasil


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