Airway epithelium mediates the anti-inflammatory effects of exercise on asthma

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author VIEIRA, Rodolfo Paula
TOLEDO, Alessandra Choqueta de FMUSP-HC
FERREIRA, Sergio Cesar
SANTOS, Angela Batista Gomes dos FMUSP-HC
MEDEIROS, Maria Cristina Rodrigues
HAGE, Marcia FMUSP-HC
MAUAD, Thais FMUSP-HC
MARTINS, Milton de Arruda FMUSP-HC
DOLHNIKOFF, Marisa FMUSP-HC
CARVALHO, Celso Ricardo Fernandes de FMUSP-HC
dc.date.issued 2011
dc.identifier.citation RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, v.175, n.3, p.383-389, 2011
dc.identifier.issn 1569-9048
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23514
dc.description.abstract Airway epithelium plays an important role in the asthma physiopathology. Aerobic exercise decreases Th2 response in murine models of allergic asthma, but its effects on the structure and activation of airway epithelium in asthma are unknown. BALB/c mice were divided into control, aerobic exercise, ovalbumin-sensitized and ovalbumin-sensitized plus aerobic exercise groups. Ovalbumin sensitization occurred on days 0, 14, 28, 42, and aerosol challenge from day 21 to day 50. Aerobic exercise started on day 22 and ended on day 50. Total cells and eosinophils were reduced in ovalbumin-sensitized group submitted to aerobic exercise. Aerobic exercise also reduced the oxidative and nitrosative stress and the epithelial expression of Th2 cytokines, chemokines, adhesion molecules, growth factors and NF-kB and P2X7 receptor. Additionally, aerobic exercise increased the epithelial expression of IL-10 in non-sensitized and sensitized animals. These findings contribute to the understanding of the beneficial effects of aerobic exercise for chronic allergic airway inflammation, suggesting an immune-regulatory role of exercise on airway epithelium.
dc.description.sponsorship · Laboratorios de Investigacao Medica da Faculdade de Medicina da Universidade de Sao Paulo (LIM-HC-FMUSP)
· Fundacao da Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2005/04413-1, 2007/01026-2]
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE BV
dc.relation.ispartof Respiratory Physiology & Neurobiology
dc.rights restrictedAccess
dc.subject Asthma; Pulmonary rehabilitation; Epithelial cells; Oxidative stress; Purinergic receptors; Growth factors
dc.subject.other nf-kappa-b; pulmonary inflammation; adhesion molecules; cells; activation; model; expression; induction; cytokines; responses
dc.title Airway epithelium mediates the anti-inflammatory effects of exercise on asthma
dc.type article
dc.rights.holder Copyright ELSEVIER SCIENCE BV
dc.description.group LIM/05
dc.description.group LIM/20
dc.identifier.doi 10.1016/j.resp.2011.01.002
dc.identifier.pmid 21236366
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author TOLEDO, Alessandra Choqueta de:FM:
hcfmusp.author SANTOS, Angela Batista Gomes dos:HC:ICHC
hcfmusp.author HAGE, Marcia:HC:ICHC
hcfmusp.author MAUAD, Thais:FM:MPT
hcfmusp.author MARTINS, Milton de Arruda:FM:MCM
hcfmusp.author DOLHNIKOFF, Marisa:FM:MPT
hcfmusp.author CARVALHO, Celso Ricardo Fernandes de:FM:MFT
hcfmusp.author.external · VIEIRA, Rodolfo Paula:Univ Sao Paulo, Sch Med, Dept Phys Therapy LIM 34, Sao Paulo, Brazil; Univ Hosp Freiburg, Dept Pneumol, COPD & Asthma Res Grp, Freiburg, Germany
· FERREIRA, Sergio Cesar:Univ Sao Paulo, Sch Med, Dept Pathol LIM 05, Sao Paulo, Brazil
· MEDEIROS, Maria Cristina Rodrigues:Univ Sao Paulo, Sch Med, Dept Pathol LIM 05, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000287896900011
hcfmusp.origem.id 2-s2.0-79751527302
hcfmusp.publisher.city AMSTERDAM
hcfmusp.publisher.country NETHERLANDS
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dc.description.index MEDLINE
hcfmusp.citation.scopus 38
hcfmusp.citation.wos 41
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Alemanha


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