Symptoms of anxiety and mood disturbance alter cardiac and peripheral autonomic control in patients with metabolic syndrome

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art_TOSCHI-DIAS_Symptoms_of_anxiety_and_mood_disturbance_alter_cardiac_2013.PDF (393.22 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2013
Editora
SPRINGER
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
SILVA, Valdo Jose Dias da
ANGELO, Luciana F.
RONDON, Maria Urbana P. B.
Autor de Grupo de pesquisa
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Citação
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v.113, n.3, p.671-679, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with MetSyn (ATP-III) were allocated to two groups, according to the levels of anxiety and mood disturbance: (1) with AMd (MetSyn + AMd, n = 15), and (2) without AMd (MetSyn, n = 11). Ten healthy control subjects were also studied (C, n = 10). AMd was determined using quantitative questionnaires. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure (oscillometric beat-to-beat basis), and heart rate (ECG) were measured during a baseline 10-min period. Spectral analysis of RR interval and systolic arterial pressure were analyzed, and the power of low (LF) and high (HF) frequency bands were determined. Sympatho-vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by calculation of alpha-index. MSNA was greater in patients with MetSyn + AMd compared with MetSyn and C. Patients with MetSyn + AMd showed higher LF and lower HF power compared with MetSyn and C. In addition, LF/HF balance was higher in MetSyn + AMd than in MetSyn and C groups. BRS was decreased in MetSyn + AMd compared with MetSyn and C groups. Anxiety and mood disturbance alter autonomic function in patients with MetSyn. This autonomic dysfunction may contribute to the increased cardiovascular risk observed in patients with mood alterations.
Palavras-chave
Anxiety, Mood disturbance, Sympathetic activity, Metabolic syndrome
URI
https://observatorio.fm.usp.br/handle/OPI/2367
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor