Negative Anti-C1q Antibody Titers May Influence Therapeutic Decisions and Reduce the Number of Renal Biopsies in Systemic Lupus Erythematosus

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art_MOURA_Negative_AntiC1q_Antibody_Titers_May_InfluenceTherapeutic_Decisions_2011.PDF (190.02 KB)
Citações na Scopus
14
Tipo de produção
article
Data de publicação
2011
Editora
KARGER
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
MOURA, Carlos Geraldo Guerreiro de
CRUZ, Luzia Arlinda Sampaio
CRUZ, Constanca Margarida Sampaio
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
NEPHRON CLINICAL PRACTICE, v.118, n.4, p.C355-C360, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
In a cross-sectional study involving 62 patients with systemic lupus erythematosus (SLE), we found that patients with biopsy-proven lupus nephritis (LN) had higher titers of anti-C1q antibodies than active SLE without nephritis patients. Anti-C1q was associated with a negative predictive value of 94.59%, a positive predictive value of 52%, a sensitivity of 86.66% and a specificity of 74.47% for the diagnosis of LN. We conclude that high titers of anti-C1q antibodies are strongly associated with the presence of active LN, and the negative predictive value of this test for diagnosing LN is very high; therefore, it can influence therapeutic decisions and reduce the number of renal biopsies in patients with SLE.
Palavras-chave
Systemic Lupus Erythematosus Disease Activity Index, Anti-C1q, Systemic lupus erythematosus, Lupus nephritis
URI
https://observatorio.fm.usp.br/handle/OPI/23700
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC