PENILE AND SCROTUM SWELLING IN JUVENILE DERMATOMYOSITIS

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SALLUM, Adriana Maluf Elias FMUSP-HC
SILVA, Marco Felipe Castro FMUSP-HC
MICHELIN, Cintia Maria
DUARTE, Ricardo Jordao FMUSP-HC
BARONI, Ronaldo Hueb FMUSP-HC
AIKAWA, Nadia Emi FMUSP-HC
SILVA, Clovis Artur FMUSP-HC
dc.date.issued 2011
dc.identifier.citation ACTA REUMATOLOGICA PORTUGUESA, v.36, n.2, p.176-179, 2011
dc.identifier.issn 0303-464X
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/23810
dc.description.abstract Edema is a well-known feature of juvenile dermatomyositis (JDM). However, to our knowledge localized penile and scrotum swelling was not previously reported. During a 27-year period, 5,506 patients were followed up at the Pediatric Rheumatology Unit of our University Hospital and 157 patients (2.9%) had JDM. One of them (0.6%) had concomitant localized penile and scrotum swelling. He had severe disease activity since he was 7-year-old, manifested by diffuse cutaneous vasculitis, recurrent localized edema (limbs or face) and only one episode of generalized edema. At the age of 10, he presented edema of the genitalia associated with mild skin erythema. Penis, scrotum and testicular ultrasound as well as magnetic resonance imaging showed skin edema without testicular involvement. He was taking prednisone, methotrexate, cyclosporin, hydroxychloroquine and thalidomide. Improvement of skin rash, penile and scrotum swelling was noticed only with rituximab therapy. No adverse event was observed during anti-CD20 infusions and after six months of follow up. Penile and scrotum edema was a rare manifestation of JDM which improved with anti-CD20 monoclonal antibody treatment.
dc.description.sponsorship · FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [08/58238, 2009/51897-5]
· CNPQ [300248/2008-3]
· Federico Foundation
dc.language.iso eng
dc.publisher MEDFARMA-EDICOES MEDICAS, LDA
dc.relation.ispartof Acta Reumatologica Portuguesa
dc.rights restrictedAccess
dc.subject Juvenile Dermatomyositis; Rituximab; Penis; Scrotum; Edema
dc.subject.other idiopathic inflammatory myopathies; membrane attack complex; disease-activity; muscle; anasarca; expression; childhood
dc.title PENILE AND SCROTUM SWELLING IN JUVENILE DERMATOMYOSITIS
dc.type article
dc.rights.holder Copyright MEDFARMA-EDICOES MEDICAS, LDA
dc.description.group LIM/36
dc.description.group LIM/44
dc.description.group LIM/55
dc.identifier.pmid 21841738
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SALLUM, Adriana Maluf Elias:HC:ICR
hcfmusp.author SILVA, Marco Felipe Castro:FM:
hcfmusp.author DUARTE, Ricardo Jordao:HC:ICHC
hcfmusp.author BARONI, Ronaldo Hueb:HC:INRAD
hcfmusp.author AIKAWA, Nadia Emi:HC:ICHC
hcfmusp.author SILVA, Clovis Artur:HC:ICR
hcfmusp.author.external · MICHELIN, Cintia Maria:Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000292531400011
hcfmusp.origem.id 2-s2.0-80052419345
hcfmusp.publisher.city ALGES
hcfmusp.publisher.country PORTUGAL
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dc.description.index MEDLINE
hcfmusp.citation.scopus 7
hcfmusp.citation.wos 5
hcfmusp.affiliation.country Brasil


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