Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author LUGARESI, Rebeca
LEME, Marco
PAINELLI, Vitor de Salles
MURAI, Igor Hisashi
ROSCHEL, Hamilton
SAPIENZA, Marcelo Tatit FMUSP-HC
LANCHA JUNIOR, Antonio Herbert
GUALANO, Bruno FMUSP-HC
dc.date.issued 2013
dc.identifier.citation JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION, v.10, article ID 26, 6p, 2013
dc.identifier.issn 1550-2783
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2391
dc.description.abstract Background: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet. Methods: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to receive either creatine (20 g/d for 5 d followed by 5 g/d throughout the trial) or placebo for 12 weeks. All of the participants were engaged in resistance training and consumed a high-protein diet (i.e., >= 1.2 g/Kg/d). Subjects were assessed at baseline (Pre) and after 12 weeks (Post). Glomerular filtration rate was measured by Cr-51-EDTA clearance. Additionally, blood samples and a 24-h urine collection were obtained for other kidney function assessments. Results: No significant differences were observed for Cr-51-EDTA clearance throughout the trial (Creatine: Pre 101.42 +/- 13.11, Post 108.78 +/- 14.41 mL/min/1.73m(2); Placebo: Pre 103.29 +/- 17.64, Post 106.68 +/- 16.05 mL/min/1.73m(2); group x time interaction: F = 0.21, p = 0.64). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria remained virtually unchanged. Conclusions: A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) e Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.language.iso eng
dc.publisher BIOMED CENTRAL LTD
dc.relation.ispartof Journal of the International Society of Sports Nutrition
dc.rights openAccess
dc.subject Glomerular filtration rate; Cr-51-EDTA clearance; Side effects
dc.subject.other renal-function; exercise; metabolism; health
dc.title Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?
dc.type article
dc.rights.holder Copyright BIOMED CENTRAL LTD
dc.description.group LIM/43
dc.identifier.doi 10.1186/1550-2783-10-26
dc.identifier.pmid 23680457
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SAPIENZA, Marcelo Tatit:HC:INRAD
hcfmusp.author GUALANO, Bruno:FM:
hcfmusp.author.external · LUGARESI, Rebeca:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
· LEME, Marco:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
· PAINELLI, Vitor de Salles:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
· MURAI, Igor Hisashi:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
· ROSCHEL, Hamilton:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil; Univ Sao Paulo, Div Rheumatol, Sch Med, BR-05508030 Sao Paulo, Brazil; Univ Sao Paulo, Lab Neuromuscular Adaptat Strength Training, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
· LANCHA JUNIOR, Antonio Herbert:Univ Sao Paulo, Lab Appl Nutr & Metab, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil
hcfmusp.origem.id WOS:000319441000001
hcfmusp.origem.id 2-s2.0-84878130794
hcfmusp.publisher.city LONDON
hcfmusp.publisher.country ENGLAND
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dc.description.index PubMed
hcfmusp.citation.scopus 17
hcfmusp.citation.wos 18
hcfmusp.affiliation.country Brasil


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