Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/24371
Title: | Monoclonal Antibodies Hypersensitivity Prevalence and Management |
Authors: | SANTOS, Rafael Bonamichi; GALVAO, Violeta Regnier |
Citation: | IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, v.37, n.4, p.695-0, 2017 |
Abstract: | The use of monoclonal antibodies (mAbs) has become broader because of their recognized effectiveness in the treatment of autoimmune, neoplastic, and inflammatory diseases. Consequently, hypersensitivity reactions (HSR) secondary to mAbs are being reported more often, and each mAb-related HSR presents specific features. This article discusses the main biological agents and associated HSR, the clinical presentation of such reactions, and the role of tryptase and skin testing in the diagnosis. Rapid drug desensitization procedures to mAbs enable selected allergic patients to receive full therapeutic doses in a safe manner and are also discussed. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/Outros Artigos e Materiais de Revistas Científicas - LIM/60 Artigos e Materiais de Revistas Científicas - ODS/03 |
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