Evaluation of the isoflavones and estrogen effects on the rat adrenal

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art_MARINHO_Evaluation_of_the_isoflavones_and_estrogen_effects_on_2017.PDF (1.03 MB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2017
Editora
TAYLOR & FRANCIS LTD
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
MARINHO, Darci Souza
CALIO, Michele Longoni
SANTOS, Miriam Aparecida
KO, Gui Mi
TEIXEIRA, Cristiane Paula
CARBONEL, Adriana Ferraz
LISBOA-NASCIMENTO, Telma
CASTRO, Rodrigo Aquino
BERTONCINI, Clelia Rejane Antonio
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
GYNECOLOGICAL ENDOCRINOLOGY, v.33, n.10, p.811-815, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The aim of this study was to evaluate the morphometry and the gene expression of Ki-67, VEGF and caspase 3 and the stress oxidative in the adrenal gland of ovariectomized rats treated with estrogen or isoflavones. We used 15 Wistar rats ovariectomized treated with isoflavones or estrogen during 30days. At the end of the treatment, the left adrenal gland was removed for subsequent histological studies and the right was used to evaluate gene expression of angiogenesis (VEGF-A), cell proliferation (Ki-67), apoptose (caspase 3 clivated) and oxidative stress. Treatment with estrogen showed a largest increase in the layers of the adrenal cortex than with isoflavones. These hypertrofic effects agree with higher expression elevation of Ki67 and VEGF, which did not occur with the caspase 3, indicating that isoflavones have great proliferative effect on the adrenal gland. Similar results were also observed on superoxide quantification show that isoflavone has a protective effect against oxidative stress. Our results indicate positively the trophic therapeutic potential of isoflavones has a protective effect and can contribute to the development of effective therapies to decrease the symptoms of menopause.
Palavras-chave
Adrenal, isoflavone, estrogen, menopause, oxidative stress
URI
https://observatorio.fm.usp.br/handle/OPI/24416
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/58