Using Exercise Training to Counterbalance Chronotropic Incompetence and Delayed Heart Rate Recovery in Systemic Lupus Erythematosus: A Randomized Trial

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP MIOSSI, Renata
PINTO, Ana Lucia de Sa FMUSP-HC
LIMA, Fernanda R. FMUSP-HC
ROSCHEL, Hamilton 2012
dc.identifier.citation ARTHRITIS CARE & RESEARCH, v.64, n.8, p.1159-1166, 2012
dc.identifier.issn 2151-464X
dc.description.abstract Objective. To evaluate the efficacy of a 3-month exercise training program in counteracting the chronotropic incompetence and delayed heart rate recovery in patients with systemic lupus erythematosus (SLE). Methods. A 12-week randomized trial was conducted. Twenty-four inactive SLE patients were randomly assigned into 2 groups: trained (T; n = 15, 3-month exercise program) and nontrained (NT; n = 13). A sex-, body mass index-, and age-matched healthy control (C) group (n = 8) also underwent the exercise program. Subjects were assessed at baseline and at 12 weeks after training. Main measurements included the chronotropic reserve (CR) and the heart rate (HR) recovery (Delta HRR) as defined by the difference between HR at peak exercise and at both the first (Delta HRR1) and second (Delta HRR2) minutes after the exercise test. Results. Neither the NT SLE patients nor the C group presented any change in the CR or in Delta HRR1 and Delta HRR2 (P > 0.05). The exercise training program was effective in promoting significant increases in CR (P = 0.007, effect size [ES] 1.15) and in Delta HRR1 and Delta HRR2 (P = 0.009, ES 1.12 and P = 0.002, ES 1.11, respectively) in the SLE T group when compared with the NT group. Moreover, the HR response in SLE patients after training achieved parameters comparable to the C group, as evidenced by the analysis of variance and by the Z score analysis (P > 0.05, T versus C). Systemic Lupus Erythematosus Disease Activity Index scores remained stable throughout the study. Conclusion. A 3-month exercise training program was safe and capable of reducing the chronotropic incompetence and the delayed Delta HRR observed in physically inactive SLE patients.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/53319-3, 2010/10749-0]
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303165/2008-1]
· Federico Foundation
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Arthritis Care & Research
dc.rights restrictedAccess
dc.subject.other rheumatoid-arthritis; accelerated atherosclerosis; autonomic dysfunction; risk-factors; disease; mortality; failure; reserve; death; index
dc.title Using Exercise Training to Counterbalance Chronotropic Incompetence and Delayed Heart Rate Recovery in Systemic Lupus Erythematosus: A Randomized Trial
dc.type article
dc.rights.holder Copyright WILEY-BLACKWELL LIM/17
dc.identifier.doi 10.1002/acr.21678
dc.identifier.pmid 22438298
dc.type.category original article
dc.type.version publishedVersion BENATTI, Fabiana B.:FM: PINTO, Ana Lucia de Sa:HC:ICHC LIMA, Fernanda R.:FM: BORBA, Eduardo F.:FM:MCM PRADO, Danilo M. L.:FM: PERANDINI, Luiz Augusto:FM: BONFA, Eloisa:FM:MCM · MIOSSI, Renata:Univ Sao Paulo, Sao Paulo, Brazil
· GUALANO, Bruno:Univ Sao Paulo, Sao Paulo, Brazil
· ROSCHEL, Hamilton:Univ Sao Paulo, Sao Paulo, Brazil 2-s2.0-84864447014 WOS:000308032900008 HOBOKEN USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 31
hcfmusp.citation.wos 31 Brasil

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