Using Exercise Training to Counterbalance Chronotropic Incompetence and Delayed Heart Rate Recovery in Systemic Lupus Erythematosus: A Randomized Trial

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MIOSSI, Renata
BENATTI, Fabiana B. FMUSP-HC
PINTO, Ana Lucia de Sa FMUSP-HC
LIMA, Fernanda R. FMUSP-HC
BORBA, Eduardo F. FMUSP-HC
PRADO, Danilo M. L. FMUSP-HC
PERANDINI, Luiz Augusto FMUSP-HC
GUALANO, Bruno
BONFA, Eloisa FMUSP-HC
ROSCHEL, Hamilton
dc.date.issued 2012
dc.identifier.citation ARTHRITIS CARE & RESEARCH, v.64, n.8, p.1159-1166, 2012
dc.identifier.issn 2151-464X
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2489
dc.description.abstract Objective. To evaluate the efficacy of a 3-month exercise training program in counteracting the chronotropic incompetence and delayed heart rate recovery in patients with systemic lupus erythematosus (SLE). Methods. A 12-week randomized trial was conducted. Twenty-four inactive SLE patients were randomly assigned into 2 groups: trained (T; n = 15, 3-month exercise program) and nontrained (NT; n = 13). A sex-, body mass index-, and age-matched healthy control (C) group (n = 8) also underwent the exercise program. Subjects were assessed at baseline and at 12 weeks after training. Main measurements included the chronotropic reserve (CR) and the heart rate (HR) recovery (Delta HRR) as defined by the difference between HR at peak exercise and at both the first (Delta HRR1) and second (Delta HRR2) minutes after the exercise test. Results. Neither the NT SLE patients nor the C group presented any change in the CR or in Delta HRR1 and Delta HRR2 (P > 0.05). The exercise training program was effective in promoting significant increases in CR (P = 0.007, effect size [ES] 1.15) and in Delta HRR1 and Delta HRR2 (P = 0.009, ES 1.12 and P = 0.002, ES 1.11, respectively) in the SLE T group when compared with the NT group. Moreover, the HR response in SLE patients after training achieved parameters comparable to the C group, as evidenced by the analysis of variance and by the Z score analysis (P > 0.05, T versus C). Systemic Lupus Erythematosus Disease Activity Index scores remained stable throughout the study. Conclusion. A 3-month exercise training program was safe and capable of reducing the chronotropic incompetence and the delayed Delta HRR observed in physically inactive SLE patients.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2011/53319-3, 2010/10749-0]
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [303165/2008-1]
· Federico Foundation
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Arthritis Care & Research
dc.rights restrictedAccess
dc.subject.other rheumatoid-arthritis; accelerated atherosclerosis; autonomic dysfunction; risk-factors; disease; mortality; failure; reserve; death; index
dc.title Using Exercise Training to Counterbalance Chronotropic Incompetence and Delayed Heart Rate Recovery in Systemic Lupus Erythematosus: A Randomized Trial
dc.type article
dc.rights.holder Copyright WILEY-BLACKWELL
dc.description.group LIM/17
dc.identifier.doi 10.1002/acr.21678
dc.identifier.pmid 22438298
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author BENATTI, Fabiana B.:FM:
hcfmusp.author PINTO, Ana Lucia de Sa:HC:ICHC
hcfmusp.author LIMA, Fernanda R.:FM:
hcfmusp.author BORBA, Eduardo F.:FM:MCM
hcfmusp.author PRADO, Danilo M. L.:FM:
hcfmusp.author PERANDINI, Luiz Augusto:FM:
hcfmusp.author BONFA, Eloisa:FM:MCM
hcfmusp.author.external · MIOSSI, Renata:Univ Sao Paulo, Sao Paulo, Brazil
· GUALANO, Bruno:Univ Sao Paulo, Sao Paulo, Brazil
· ROSCHEL, Hamilton:Univ Sao Paulo, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84864447014
hcfmusp.origem.id WOS:000308032900008
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
hcfmusp.relation.reference · Adams BJ, 2008, AM J CARDIOL, V101, P1403, DOI 10.1016/j.amjcard.2008.01.016
· Aydemir M, 2010, LUPUS, V19, P255, DOI 10.1177/0961203309351540
· Azarbal B, 2004, J AM COLL CARDIOL, V44, P423, DOI 10.1016/j.jacc.2004.02.060
· BOMBARDIER C, 1992, ARTHRITIS RHEUM, V35, P630, DOI 10.1002/art.1780350606
· Braga A, 2005, CARDIOLOGIA EXERCICI, P128
· Bruce IN, 2005, RHEUMATOLOGY, V44, P1492, DOI 10.1093/rheumatology/kei142
· Carter JB, 2003, SPORTS MED, V33, P33, DOI 10.2165/00007256-200333010-00003
· Chung CP, 2007, ANN RHEUM DIS, V66, P208, DOI 10.1136/ard.2006.054973
· Cohen J., 1988, STAT POWER ANAL BEHA
· Dimopoulos S, 2006, EUR J CARDIOV PREV R, V13, P67, DOI 10.1097/00149831-200602000-00010
· Dogdu O, 2010, J RHEUMATOL, V37, P2511, DOI 10.3899/jrheum.100163
· do Prado DML, 2011, LUPUS, V20, P717, DOI 10.1177/0961203310397081
· Doria A, 2008, NAT CLIN PRACT RHEUM, V4, P576, DOI 10.1038/ncprheum0899
· Edwards KM, 2011, ACTA PHYSIOL, V203, P343, DOI 10.1111/j.1748-1716.2011.02329.x
· El Magadmi M, 2006, J RHEUMATOL, V33, P50
· Esdaile JM, 2001, ARTHRITIS RHEUM, V44, P2331, DOI 10.1002/1529-0131(200110)44:10<2331::AID-ART395>3.0.CO;2-I
· Keteyian SJ, 1999, AM HEART J, V138, P233, DOI 10.1016/S0002-8703(99)70106-7
· Milovanovic B, 2010, SRP ARK CELOK LEK, V138, P26, DOI 10.2298/SARH1002026M
· Nishime EO, 2000, JAMA-J AM MED ASSOC, V284, P1392, DOI 10.1001/jama.284.11.1392
· Rosenwinkel Eric T., 2001, Cardiology Clinics, V19, P369, DOI 10.1016/S0733-8651(05)70223-X
· Routledge FS, 2010, CAN J CARDIOL, V26, P303
· Sato H, 2007, CLIN CHIM ACTA, V385, P35, DOI 10.1016/j.cca.2007.04.023
· Saunders JA, 2006, SOC WORK RES, V30, P19
· Stojanovich L, 2007, LUPUS, V16, P181, DOI 10.1177/0961203306076223
· TAN EM, 1982, ARTHRITIS RHEUM, V25, P1271, DOI 10.1002/art.1780251101
· Tulppo MP, 1998, AM J PHYSIOL-HEART C, V274, pH424
· Vinik AI, 2011, DIABETIC MED, V28, P643, DOI 10.1111/j.1464-5491.2010.03184.x
· White Ian R, 2011, BMJ, V342, pd40, DOI 10.1136/bmj.d40
dc.description.index MEDLINE
hcfmusp.citation.scopus 31
hcfmusp.citation.wos 31
hcfmusp.affiliation.country Brasil


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace



Browse

My Account

Statistics