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https://observatorio.fm.usp.br/handle/OPI/24935
Title: | Grey and white matter volumes either in treatment-naive or hormone-treated transgender women: a voxel-based morphometry study |
Authors: | SPIZZIRRI, Giancarlo; DURAN, Fabio Luis Souza; CHAIM-AVANCINI, Tiffany Moukbel; SERPA, Mauricio Henriques; CAVALLET, Mikael; PEREIRA, Carla Maria Abreu; SANTOS, Pedro Paim; SQUARZONI, Paula; COSTA, Naomi Antunes da; BUSATTO, Geraldo F.; ABDO, Carmita Helena Najjar |
Citation: | SCIENTIFIC REPORTS, v.8, article ID 736, 10p, 2018 |
Abstract: | Many previous magnetic resonance imaging (MRI) studies have documented sex differences in brain morphology, but the patterns of sexual brain differences in transgender women - male sex assigned at birth - with a diagnosis of gender dysphoria (TW) have been rarely investigated to date. We acquired T1-weighted MRI data for the following four (n = 80) groups: treatment-naive TW (TNTW), TW treated with cross-sex hormones for at least one year (TTW), cisgender men, and cisgender women (cisgender individuals as controls). Differences in whole-brain and regional white matter volume and grey matter volume (GMV) were assessed using voxel-based morphometry. We found lower global brain volumes and regional GMVs in a large portion of the posterior-superior frontal cortex in the cisgender women group than in the TTW and cisgender men groups. Additionally, both transgender groups exhibited lower bilateral insular GMVs than the cisgender women group. Our results highlight differences in the insula in both transgender groups; such differences may be characteristic of TW. Furthermore, these alterations in the insula could be related to the neural network of body perception and reflect the distress that accompanies gender dysphoria. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/21 Artigos e Materiais de Revistas Científicas - ODS/05 |
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art_SPIZZIRRI_Grey_and_white_matter_volumes_either_in_treatmentnaive_2018.PDF | publishedVersion (English) | 1.45 MB | Adobe PDF | View/Open |
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