Cutting Edge: Brazilian Pemphigus Foliaceus Anti-Desmoglein 1 Autoantibodies Cross-React with Sand Fly Salivary LJM11 Antigen

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author QIAN, Ye
JEONG, Joseph S.
MALDONADO, Mike
VALENZUELA, Jesus G.
GOMES, Regis
TEIXEIRA, Clarissa
EVANGELISTA, Flor
QAQISH, Bahjat
AOKI, Valeria FMUSP-HC
HANS JR., Gunter
RIVITTI, Evandro A. FMUSP-HC
EATON, Donald
DIAZ, Luis A.
dc.date.issued 2012
dc.identifier.citation JOURNAL OF IMMUNOLOGY, v.189, n.4, p.1535-1539, 2012
dc.identifier.issn 0022-1767
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2517
dc.description.abstract The environmental factors that contribute to the development of autoimmune diseases are largely unknown. Endemic pemphigus foliaceus in humans, known as Fogo Selvagem (FS) in Brazil, is mediated by pathogenic IgG4 autoantibodies against desmoglein 1 (Dsg1). Clusters of FS overlap with those of leishmaniasis, a disease transmitted by sand fly (Lutzomyia longipalpis) bites. In this study, we show that salivary Ags from the sand fly, and specifically the LJM11 salivary protein, are recognized by FS Abs. Anti-Dsg1 monoclonal autoantibodies derived from FS patients also cross-react with LJM11. Mice immunized with LJM11 generate anti-Dsg1 Abs. Thus, insect bites may deliver salivary Ags that initiate a cross-reactive IgG4 Ab response in genetically susceptible individuals and lead to subsequent FS. Our findings establish a clear relationship between an environmental, noninfectious Ag and the development of potentially pathogenic autoantibodies in an autoimmune disease. The Journal of Immunology, 2012, 189: 1535-1539.
dc.description.sponsorship · National Institutes of Health (NIH) [R01 AR30281, R01 AR32599, K01 AR056378]
· Dermatology Foundation research award
· American Skin Association Alice P. Melly research grant
dc.language.iso eng
dc.publisher AMER ASSOC IMMUNOLOGISTS
dc.relation.ispartof Journal of Immunology
dc.rights restrictedAccess
dc.subject.other fogo selvagem; lutzomyia-longipalpis; immunotherapy; antibodies; vulgaris; chagasi; disease; epitope; vector; vitro
dc.title Cutting Edge: Brazilian Pemphigus Foliaceus Anti-Desmoglein 1 Autoantibodies Cross-React with Sand Fly Salivary LJM11 Antigen
dc.type article
dc.rights.holder Copyright AMER ASSOC IMMUNOLOGISTS
dc.description.group LIM/56
dc.identifier.doi 10.4049/jimmunol.1200842
dc.identifier.pmid 22798673
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author AOKI, Valeria:FM:MDT
hcfmusp.author RIVITTI, Evandro A.:FM:MDT
hcfmusp.author.external · QIAN, Ye:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA
· JEONG, Joseph S.:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA
· MALDONADO, Mike:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA
· VALENZUELA, Jesus G.:NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA
· GOMES, Regis:NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA
· TEIXEIRA, Clarissa:NIAID, Vector Mol Biol Sect, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA
· EVANGELISTA, Flor:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA
· QAQISH, Bahjat:Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA
· HANS JR., Gunter:Univ Fed Mato Grosso do Sul, Dept Dermatol, BR-79070900 Mato Grosso, Brazil
· EATON, Donald:Univ Fed Mato Grosso do Sul, Dept Dermatol, BR-79070900 Mato Grosso, Brazil
· DIAZ, Luis A.:Univ N Carolina, Dept Dermatol, Chapel Hill, NC 27599 USA
hcfmusp.origem.id 2-s2.0-84864822852
hcfmusp.origem.id WOS:000307216000002
hcfmusp.publisher.city BETHESDA
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 41
hcfmusp.citation.wos 35
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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