Ethical Issues in the Use of Animal Models for Tissue Engineering: Reflections on Legal Aspects, Moral Theory, Three Rs Strategies, and Harm-Benefit Analysis

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art_LIGUORI_Ethical_Issues_in_the_Use_of_Animal_Models_2017.PDF (395.12 KB)
Citações na Scopus
25
Tipo de produção
article
Data de publicação
2017
Editora
MARY ANN LIEBERT, INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
JERONIMUS, Bertus F.
LIGUORI, Tacia T. de Aquinas
HARMSEN, Martin C.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
TISSUE ENGINEERING PART C-METHODS, v.23, n.12, Special Issue, p.850-862, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Animal experimentation requires a solid and rational moral foundation. Objective and emphatic decision-making and protocol evaluation by researchers and ethics committees remain a difficult and sensitive matter. This article presents three perspectives that facilitate a consideration of the minimally acceptable standard for animal experiments, in particular, in tissue engineering (TE) and regenerative medicine. First, we review the boundaries provided by law and public opinion in America and Europe. Second, we review contemporary moral theory to introduce the Neo-Rawlsian contractarian theory to objectively evaluate the ethics of animal experiments. Third, we introduce the importance of available reduction, replacement, and refinement strategies, which should be accounted for in moral decision-making and protocol evaluation of animal experiments. The three perspectives are integrated into an algorithmic and graphic harm-benefit analysis tool based on the most relevant aspects of animal models in TE. We conclude with a consideration of future avenues to improve animal experiments.
Palavras-chave
animal experimentation, animal use alternatives, morals, research ethics, tissue engineering, regulatory aspects
URI
https://observatorio.fm.usp.br/handle/OPI/25515
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11