RET-Rearranged Lung Cancer

Abstract

In recent years, we have witnessed the discovery of several oncogenic driver mutations as well as the emergence of specific inhibitors with high response rates and few treatment-related adverse events. RET-rearranged lung cancers represent a small subset of lung cancer, most commonly encountered in patients with adenocarcinoma and minimal or no exposure to tobacco. Several multikinase inhibitors have been tested with high ""off-target"" toxicity and low RET inhibition activity. Early-phase clinical trials with more selective inhibitors are awaited. Here, we review the main aspects of the biology of RET, the challenges of RET inhibition in lung cancer, and some future perspectives.