Genomic analysis of head and neck cancer cases from two high incidence regions

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art_PERDOMO_Genomic_analysis_of_head_and_neck_cancer_cases_2018.PDF (5.6 MB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2018
Editora
PUBLIC LIBRARY SCIENCE
DOI
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Scopus
Web of Science
PubMed
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Título do Volume
Autores
PERDOMO, Sandra
ANANTHARAMAN, Devasena
FOLL, Matthieu
ABEDI-ARDEKANI, Behnoush
DURAND, Geoffroy
HOLMILA, Reetta
CALVEZ-KELM, Florence Le
TAJARA, Eloiza H.
WUNSCH-FILHO, Victor
Autor de Grupo de pesquisa
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Coordenadores
Organizadores
Citação
PLOS ONE, v.13, n.1, article ID e0191701, 18p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
We investigated how somatic changes in HNSCC interact with environmental and host risk factors and whether they influence the risk of HNSCC occurrence and outcome. 180-paired samples diagnosed as HNSCC in two high incidence regions of Europe and South America underwent targeted sequencing (14 genes) and evaluation of copy number alterations (SCNAs). TP53, PIK3CA, NOTCH1, TP63 and CDKN2A were the most frequently mutated genes. Cases were characterized by a low copy number burden with recurrent focal amplification in 11q13.3 and deletion in 15q22. Cases with low SCNAs showed an improved overall survival. We found significant correlations with decreased overall survival between focal amplified regions 4p16, 10q22 and 22q11, and losses in 12p12, 15814 and 15q22. The mutational landscape in our cases showed an association to both environmental exposures and clinical characteristics. We confirmed that somatic copy number alterations are an important predictor of HNSCC overall survival.
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URI
https://observatorio.fm.usp.br/handle/OPI/25855
Referências
  1. Aeberhard WH, 2014, BIOMETRICS, V70, P920, DOI 10.1111/biom.12212
  2. Agrawal N, 2011, SCIENCE, V333, P1154, DOI 10.1126/science.1206923
  3. Anantharaman D, 2017, INT J CANCER, V140, P1968, DOI 10.1002/ijc.30608
  4. Anantharaman D, 2013, JNCI-J NATL CANCER I, V105, P536, DOI 10.1093/jnci/djt053
  5. Andor N., 2015, NAT MED
  6. Benjamini Y, 1995, J ROYAL STAT SOC B, V57
  7. Castellsague X, 2016, J NATL CANC I, V108
  8. Cerami E, 2012, CANCER DISCOV, V2, P401, DOI 10.1158/2159-8290.CD-12-0095
  9. Chatenoud L, 2014, ANN ONCOL, V25, P1843, DOI 10.1093/annonc/mdu206
  10. Ciriello G, 2013, NAT GENET, V45, P1127, DOI 10.1038/ng.2762
  11. Dai M, 2004, CANCER RES, V64, P468, DOI 10.1158/0008-5472.CAN-03-3284
  12. Ervik M. FL, 2016, CANC TODAY LYON FRAN
  13. Feenstra M, 1999, TISSUE ANTIGENS, V54, P235, DOI 10.1034/j.1399-0039.1999.540304.x
  14. Ferlay J SI, 2014, GLOBOCAN 2012 V1 0 C
  15. Fernandez-Cuesta L, 2016, EBIOMEDICINE
  16. Gombe Mbalawa C, 2013, CANC INCIDENCE 5 CON, VX
  17. Gao J., 2013, SCI SIGNAL, V6, pl1, DOI 10.1126/SCISIGNAL.2004088
  18. Gatta G, 2015, EUR J CANC
  19. Giudice FS, 2013, J CARCINOG MUTAGE S5
  20. Gross AM, 2014, NAT GENET, V46, P939, DOI 10.1038/ng.3051
  21. Hayes DN, 2015, J CLIN ONCOL, V33, P3227, DOI 10.1200/JCO.2015.62.1086
  22. Hedberg ML, 2016, J CLIN INVEST, V126, P169, DOI 10.1172/JCI82066
  23. Herrero R, 2003, J NATL CANCER I, V95, P1772, DOI 10.1093/jnci/djg/107
  24. Imai FL, 2001, INT J MOL MED, V7, P43
  25. India Project Team of the International Cancer Genome Consortium, 2013, NAT COMMUN, V4, P2873, DOI [10.1038/ncomms3873, DOI 10.1038/NC0MMS3873]
  26. Keck MK, 2015, CLIN CANCER RES, V21, P870, DOI 10.1158/1078-0432.CCR-14-2481
  27. Kim KT, 2016, HEAD NECK-J SCI SPEC, V38, pE2021, DOI 10.1002/hed.24372
  28. Kim YH, 2010, ONCOGENE, V29, P1421, DOI 10.1038/onc.2009.437
  29. Kreimer AR, 2013, J CLIN ONCOL, V31, P2708, DOI 10.1200/JCO.2012.47.2738
  30. Lagiou P, 2009, EUR J CANCER PREV, V18, P76, DOI 10.1097/CEJ.0b013e32830c8dca
  31. Lawrence MS, 2015, NATURE, V517, P576, DOI 10.1038/nature14129
  32. Le Calvez-Kelm F, 2016, ONCOTARGET, V7, P78827, DOI 10.18632/oncotarget.12386
  33. Lui VWY, 2013, CANCER DISCOV, V3, P761, DOI 10.1158/2159-8290.CD-13-0103
  34. MacDonald JR, 2014, NUCLEIC ACIDS RES, V42, pD986, DOI 10.1093/nar/gkt958
  35. Lopez RVM, 2014, CANCER CAUSE CONTROL, V25, P461, DOI 10.1007/s10552-014-0348-8
  36. Mermel CH, 2011, GENOME BIOL, V12, DOI 10.1186/gb-2011-12-4-r41
  37. Mo QX, 2013, P NATL ACAD SCI USA, V110, P4245, DOI 10.1073/pnas.1208949110
  38. Morris LG, 2016, JAMA ONCOL
  39. Mroz EA, 2015, PLOS MED, V12, DOI 10.1371/journal.pmed.1001786
  40. Neskey DM, 2015, CANCER RES, V75, P1527, DOI 10.1158/0008-5472.CAN-14-2735
  41. Oh JE, 2015, J NEUROPATH EXP NEUR, V74, P952, DOI 10.1097/NEN.0000000000000238
  42. Pena-Alonso E, 2008, CANCER LETT, V263, P89, DOI 10.1016/j.canlet.2007.12.029
  43. Perez-Llamas C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019541
  44. Peters HL, 2011, IMMUNOL RES, V51, P39, DOI 10.1007/s12026-011-8238-6
  45. Pickering CR, 2013, CANCER DISCOV, V3, P770, DOI 10.1158/2159-8290.CD-12-0537
  46. Poeta ML, 2007, NEW ENGL J MED, V357, P2552, DOI 10.1056/NEJMoa073770
  47. Pulte D, 2010, ONCOLOGIST, V15, P994, DOI 10.1634/theoncologist.2009-0289
  48. Reddy RB, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0147409
  49. Reuschenbach M, 2008, INT J CANCER, V123, P2626, DOI 10.1002/ijc.23837
  50. Rodrigo JP, 2011, HEAD NECK-J SCI SPEC, V33, P1708, DOI 10.1002/hed.21661
  51. Scharpf RB, 2011, J STAT SOFTW, V40, P1
  52. Seiwert TY, 2015, CLIN CANCER RES, V21, P632, DOI 10.1158/1078-0432.CCR-13-3310
  53. Smeets SJ, 2009, CELL ONCOL, V31, P291, DOI 10.3233/CLO-2009-0471
  54. Stoepker C, 2015, CANCER RES, V75, P3543, DOI 10.1158/0008-5472.CAN-15-0528
  55. Stransky N, 2011, SCIENCE, V333, P1157, DOI 10.1126/science.1208130
  56. Sweeny L, 2012, LARYNGOSCOPE, V122, P1539, DOI 10.1002/lary.23266
  57. Szymanska K, 2011, CANCER CAUSE CONTROL, V22, P1037, DOI 10.1007/s10552-011-9779-7
  58. Taberna M, 2017, ANN ONCOL
  59. Vairaktaris E, 2006, ANTICANCER RES, V26, P4217
  60. Wang K, 2010, NUCLEIC ACIDS RES, V38, pe164, DOI 10.1093/NAR/GKQ603
  61. World Health Organization International Agency for Research on Cancer, 2012, IARC MONOGR EVAL CAR, V100, P1
  62. Yanagi H, 2012, BIOCHEM BIOPH RES CO, V418, P104, DOI 10.1016/j.bbrc.2011.12.142
  63. Zack TI, 2013, NAT GENET, V45, P1134, DOI 10.1038/ng.2760
  64. Zhou G, 2016, J CELL BIOCHEM, V117, P2682, DOI 10.1002/jcb.25592

Coleções
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - ODS/03