Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/25858
Title: Identification and antifungal susceptibility of Candida species isolated from the urine of patients in a university hospital in Brazil
Authors: LIMA, Glaucia Moreira EspindolaNUNES, Maina de OliveiraCHANG, Marilene RodriguesTSUJISAKI, Rosianne Assis de SousaNUNES, Joslaine de OliveiraTAIRA, Cleison LedesmaTHOMAZ, Danilo YamamotoNEGRO, Gilda Maria Barbaro DelMENDES, Rinaldo PoncioPANIAGO, Anamaria Mello Miranda
Citation: REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.59, article ID UNSP e75, 8p, 2017
Abstract: The aim of this study was to identify Candida spp. isolated from candiduria episodes at a tertiary hospital in the Midwest region of Brazil, and to determine their susceptibility profiles to antifungal compounds. From May 2011 to April 2012, Candida spp. isolated from 106 adult patients with candiduria admitted to the University Hospital of the Federal University of Mato Grosso do Sul were evaluated. Both, species identification and susceptibility testing with fluconazole-FLC, voriconazole-VRC, and amphotericin B-AmB were carried out using the Vitek 2. To discriminate species of the C. parapsilosis complex, a RAPD-PCR technique using the RPO2 primer was performed. From the total of 106 isolates, 42 (39.6%) C. albicans and 64 (60.4%) Candida non-albicans (CNA) -33 C. tropicalis, 18 C. glabrata, 5 C. krusei, 4 C. parapsilosis sensu stricto, 2 C. kefyr, 1 C. lusitaniae, and 1 C. guilliermondii were identified. All isolates were susceptible to AmB and VRC, whereas all C. glabrata isolates presented either resistance (5.6%) or dose-dependent susceptibility (94.4%) to FLC. The study of Candida spp. and their resistance profiles may help in tailoring more efficient therapeutic strategies for candiduria.
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Artigos e Materiais de Revistas Científicas - LIM/53
LIM/53 - Laboratório de Micologia


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