MAIT cells are activated in acute Dengue virus infection and after in vitro Zika virus infection

Imagem de Miniatura
Arquivos
art_PAQUIN-PROULX_MAIT_cells_are_activated_in_acute_Dengue_virus_2018.PDF (5.62 MB)
Citações na Scopus
38
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
PAQUIN-PROULX, Dominic
BARSOTTI, Nathalia Silveira
SIROMA, Fabiana
Citação
PLOS NEGLECTED TROPICAL DISEASES, v.12, n.1, article ID e0006154, 15p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Dengue virus (DENV) and Zika virus (ZIKV) are members of the Flaviviridae and are pre-dominantly transmitted via mosquito bites. Both viruses are responsible for a growing number of infections in tropical and subtropical regions. DENV infection can cause lethargy with severe morbidity and dengue shock syndrome leading to death in some cases. ZIKV is now linked with Guillain-Barre A syndrome and fetal malformations including microcephaly and developmental disorders (congenital Zika syndrome). The protective and pathogenic roles played by the immune response in these infections is unknown. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells with potent anti-bacterial activity. MAIT cells have also been postulated to play a role in the immune response to viral infections. In this study, we evaluated MAIT cell frequency, phenotype, and function in samples from subjects with acute and convalescent DENV infection. We found that in acute DENV infection, MAIT cells had elevated co-expression of the activation markers CD38 and HLA-DR and had a poor IFN gamma response following bacterial stimulation. Furthermore, we found that MAIT cells can produce IFN gamma in response to in vitro infection with ZIKV. This MAIT cell response was independent of MR1, but dependent on IL-12 and IL-18. Our results suggest that MAIT cells may play an important role in the immune response to Flavivirus infections.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/26255
Referências
  1. Bhatt S, 2013, NATURE, V496, P504, DOI 10.1038/nature12060
  2. Calvet GA, 2016, J CLIN VIROL, V74, P1, DOI 10.1016/j.jcv.2015.11.014
  3. Cao-Lormeau VM, 2016, LANCET, V387, P1531, DOI 10.1016/S0140-6736(16)00562-6
  4. Cosgrove C, 2013, BLOOD, V121, P951, DOI 10.1182/blood-2012-06-436436
  5. de Matos AM, 2015, PLOS NEGLECT TROP D, V9, DOI 10.1371/journal.pntd.0003520
  6. Delvecchio R, 2016, VIRUSES, V8
  7. Dias J, 2017, P NATL ACAD SCI US
  8. Dias J, 2016, J LEUKOCYTE BIOL, V100, P233, DOI 10.1189/jlb.4TA0815-391RR
  9. Fagundes CT, 2011, PLOS NEGLECT TROP D, V5, DOI 10.1371/journal.pntd.0001449
  10. Gold MC, 2014, J EXP MED, V211, P1601, DOI 10.1084/jem.20140507
  11. Hengst J, 2016, EUR J IMMUNOL, V46, P2204, DOI 10.1002/eji.201646447
  12. Joao Esau Custodio, 2017, Pediatr Infect Dis J, V36, P500, DOI 10.1097/INF.0000000000001482
  13. Kjer-Nielsen L, 2012, NATURE, V491, P717, DOI 10.1038/nature11605
  14. Le Bourhis L, 2010, NAT IMMUNOL, V11, P701, DOI 10.1038/ni.1890
  15. Leeansyah E, 2015, PLOS PATHOG, V11, DOI 10.1371/journal.ppat.1005072
  16. Leeansyah E, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4143
  17. Leeansyah E, 2013, BLOOD, V121, P1124, DOI 10.1182/blood-2012-07-445429
  18. Leeansyah E, 2013, CURR OPIN HIV AIDS, V8, P117, DOI 10.1097/COH.0b013e32835c7134
  19. Li J, 2016, AUSTRALAS J DERMATOL
  20. Loh L, 2016, P NATL ACAD SCI USA, V113, P10133, DOI 10.1073/pnas.1610750113
  21. Messina JP, 2016, ELIFE, V5, DOI 10.7554/eLife.15272
  22. Mustafa AS, 2001, FEMS IMMUNOL MED MIC, V30, P229, DOI 10.1016/S0928-8244(01)00227-9
  23. Pacsa AS, 2000, FEMS IMMUNOL MED MIC, V28, P151, DOI 10.1016/S0928-8244(00)00147-4
  24. Pal T, 2014, J CLIN VIROL, V61, P365, DOI 10.1016/j.jcv.2014.09.003
  25. Pang JX, 2015, AM J TROP MED HYG, V92, P1156, DOI 10.4269/ajtmh.15-0031
  26. Paquin-Proulx D, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0175345
  27. Paquin-Proulx D, 2017, IMMUNOHORIZON, V1, P141
  28. Penot P, 2017, EURO SURVEILL, V22
  29. Rasmussen SA, 2016, NEW ENGL J MED, V374, P1981, DOI 10.1056/NEJMsr1604338
  30. Reantragoon R, 2013, J EXP MED, V210, P2305, DOI 10.1084/jem.20130958
  31. Rothman AL, 2011, NAT REV IMMUNOL, V11, P532, DOI 10.1038/nri3014
  32. Salou M, 2017, CURR OPIN IMMUNOL, V48, P7, DOI 10.1016/j.coi.2017.07.009
  33. Tang XZ, 2013, J IMMUNOL, V190, P3142, DOI 10.4049/jimmunol.1203218
  34. Teunissen MBM, 2014, J INVEST DERMATOL, V134, P2898, DOI 10.1038/jid.2014.261
  35. Treiner E, 2003, NATURE, V422, P164, DOI 10.1038/nature01433
  36. Ussher JE, 2014, EUR J IMMUNOL, V44, P195, DOI 10.1002/eji.201343509
  37. van de Weg CAM, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002236
  38. van de Weg CAM, 2012, J CLIN VIROL, V53, P38, DOI 10.1016/j.jcv.2011.09.028
  39. van Wilgenburg B, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11653
  40. Yauch LE, 2009, J IMMUNOL, V182, P4865, DOI 10.4049/jimmunol.0801974

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/37
Artigos e Materiais de Revistas Científicas - LIM/49
Carregar mais