Oral shedding of human herpesviruses in renal transplant recipients

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art_SARMENTO_Oral_shedding_of_human_herpesviruses_in_renal_transplant_2018.PDF (383.74 KB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
SARMENTO, Dmitry Jose de Santana
PALLOS, Debora
CALIENTO, Rubens
PALMIERI, Michelle
MARTINS, Victor Adriano de Oliveira
GALLOTTINI, Marina
Citação
CLINICAL ORAL INVESTIGATIONS, v.22, n.2, p.885-891, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
To describe the shedding profile of human herpesviruses in the saliva of renal transplant recipients. This is a prospective case-control study of 50 renal transplant recipients and control group of 50 individuals (non-transplanted and immunocompetent). Mouthwash samples were collected via oral rinse and then submitted to screening for the presence of eight types of herpesviruses by using multiplex PCR. Fisher's exact, chi-square, and Student t tests were used for statistical analysis, and the significance level was set at 5%. The mean age of the study group was 49.42 +/- 12.94 years, 28/50 (56%) were female, and the time elapsed after transplantation was 68.20 +/- 67.19 months. Herpes simplex virus 1 (HSV-1) (P = 0.025) and Epstein-Barr virus (EBV) (P = 0.024) were, statistically, more excreted in the saliva of renal transplant recipients compared to control group. Gender (P = 1.00) and age (P = 0.563) did not influence the salivary shedding of herpesviruses in renal transplant recipients. Individuals who excreted varicella-zoster virus in saliva had a shorter mean time of transplantation (22:00 + 2.82 months) (P < 0.001). Renal transplant recipients excreted herpesviruses more often than controls, especially HSV-1 and EBV, with salivary shedding of herpesviruses being more frequent in patients with recent kidney transplantation. The present findings support other longitudinal studies evaluating the relationship between oral shedding of human herpesviruses and clinical presence of active infection and renal transplant failure.
Palavras-chave
Human herpesviruses, Kidney transplantation, Saliva, Oral shedding
URI
https://observatorio.fm.usp.br/handle/OPI/26334
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/47
Artigos e Materiais de Revistas Científicas - LIM/52