Are prematurity and environmental factors determinants for developing childhood-onset systemic lupus erythematosus?
Carregando...
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2018
Editora
TAYLOR & FRANCIS LTD
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
MODERN RHEUMATOLOGY, v.28, n.1, p.156-160, 2018
Resumo
Objective: The objective of this study is to evaluate the influence of exposure to air pollutants and inhalable environmental elements during pregnancy and after birth until childhood-onset systemic lupus erythematosus(cSLE) diagnosis. Methods: This case-control study comprised 30 cSLE patients and 86 healthy controls living in the Sao Paulo metropolitan area. A structured and reliable questionnaire (kappa index for test-retest was 0.78) assessed demographic data, gestational and perinatal-related-factors, and exposure to inhalable particles and/or volatile vapor, and/or tobacco, as well as, the presence of industrial activities or gas stations near the home/work/daycare/school). Tropospheric pollutants included: particulate matter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O-3) and carbon monoxide (CO). Results: The median current age was similar between cSLE patients and healthy controls [16.0 (5-21) versus 15.0 (4-21) years, p = .32], likewise the frequency of female gender (87% versus 78%, p = .43). The frequencies of prematurity (30% versus 6%, p = .001), maternal occupational exposure during pregnancy (59% versus 12%, p < .001), exposure to volatile vapor (48% versus 8%, p < .001) and fetal smoking (maternal and/or secondhand) (37% versus 19%, p = .008) were significantly higher in cSLE patients compared with controls. In a multivariate analysis regarding the gestation period, maternal occupational exposure (OR 13.5, 95% CI 2.5-72.4, p = .002), fetal smoking (OR 8.6, 95% CI 1.6-47, p = .013) and prematurity (OR 15.8, 95% CI 1.9-135.3, p = .012) remained risk factors for cSLE development. Furthermore, exposure to secondhand smoking during pregnancy and after birth (OR 9.1, 95% CI 1.8-42.1, p = .002) was also a risk factor for cSLE development. Conclusions: Prematurity and environmental factors were risk factors for developing cSLE.
Palavras-chave
Childhood-onset systemic lupus erythematosus, environmental factor, smoking, air pollution, maternal occupational exposure
Referências
- Bernatsky S, 2011, ENVIRON HEALTH PERSP, V119, P45, DOI 10.1289/ehp.1002123
- DiPietro NA, 2010, PHARMACOTHERAPY, V30, P973, DOI 10.1592/phco.30.10.973
- Engle WA, 2008, CLIN PERINATOL, V35, P325, DOI 10.1016/j.clp.2008.03.003
- Farhat SCL, 2011, AUTOIMMUN REV, V11, P14, DOI 10.1016/j.autrev.2011.06.008
- Fernandes EC, 2015, ARTHRIT CARE RES, V67, P1609, DOI 10.1002/acr.22603
- Guimarães Mariana Tavares, 2011, Rev. bras. epidemiol., V14, P598, DOI 10.1590/S1415-790X2011000400007
- Hochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928
- Klumb EM, 2015, REV BRAS REUMATOL, V55, P1, DOI 10.1016/j.rbr.2014.09.008
- Li S, 2014, OBES REV, V15, P804, DOI 10.1111/obr.12214
- McKinney PA, 2008, RADIAT PROT DOSIM, V132, P232, DOI 10.1093/rpd/ncn265
- Morales E, 2016, INT J EPIDEMIOL, V45, P1644, DOI 10.1093/ije/dyw196
- Novak GV, 2017, AUTOIMMUN REV, V16, P132, DOI 10.1016/j.autrev.2016.12.004
- Orione MAM, 2014, ARTHRIT CARE RES, V66, P1571, DOI 10.1002/acr.22358
- Parets Sasha E, 2014, Biology (Basel), V3, P498, DOI 10.3390/biology3030498
- Pilli L, 2013, CRITERIO PADRAO CLAS
- Shea AK, 2008, NICOTINE TOB RES, V10, P267, DOI 10.1080/14622200701825908
- Shenoi S, 2016, ARTHRIT CARE RES, V68, P1186, DOI 10.1002/acr.22806
- Silva CA, 2016, EXPERT REV CLIN IMMU, V12, P907, DOI 10.1080/1744666X.2016.1195685
- Silva CA, 2016, EXPERT REV CLIN IMMU, V12, P301, DOI 10.1586/1744666X.2016.1123621
- Simard JF, 2009, LUPUS, V18, P431, DOI 10.1177/0961203308098186
- Too CL, 2016, ANN RHEUM DIS, V75, P997, DOI 10.1136/annrheumdis-2015-208278
- Vidotto JP, 2012, LUPUS, V21, P526, DOI 10.1177/0961203312437806
- Voort AMMSVD, 2014, J ALLERGY CLIN IMMUN, V133, P1317, DOI 10.1016/j.jaci.2013.12.1082
- Zhou YF, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110466
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/36
Carregar mais Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/36