F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ALVES, Christiano R. R.
FARIA, Daniele de P. FMUSP-HC
CARNEIRO, Camila de G.
GARCEZ, Alexandre T. FMUSP-HC
GUTIERREZ, Vanessa P.
NEVES, Willian das
ALMEIDA, Ney R. de
CURY, Yara
CHAMMAS, Roger FMUSP-HC
BRUM, Patricia C.
dc.date.issued 2018
dc.identifier.citation LIFE SCIENCES, v.206, p.29-34, 2018
dc.identifier.issn 0024-3205
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/26912
dc.description.abstract Noninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal studies. The present study was designed to evaluate the potential of PET/CT and SPECT/CT as research tools to detect bone cancer in rats. We used a rat model of bone cancer induced by injecting Walker 256 tumor cells into the femoral cavity. Computed tomography demonstrated that rats presented a solid tumor at 15 days post injection (dpi). However, CT was not an effective method for identifying tumors at an earlier time point (8 dpi), when mechanical hyperalgesia (the most common symptom during bone cancer progression) had already initiated. At this early stage, PET/CT and SPECT/CT analysis detected higher uptake in the injected femur of the tracers F-18-Fluoride and Tc-99m-Methyl diphosphonate (Tc-99m-MDP), respectively. These findings demonstrated for the first time that both F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect cancer at early stages in rats and advocates for the PET/SPECT/CT as research tools to evaluate bone cancer in further longitudinal studies involving small animals.
dc.description.sponsorship · Sao Paulo Research Foundation, Sao Paulo, Brazil (FAPESP) [16/01478-0, 14/03016-8, 12/25240-1, 12/02528-0]
· FAPESP [15/22814-5]
dc.language.iso eng
dc.publisher PERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartof Life Sciences
dc.rights restrictedAccess
dc.subject Imaging; Oncology; Cancer pain; Bone metabolism; Small animal models
dc.subject.other tumor-bearing rats; animal-models; pain; cachexia; metabolism; disease; cells
dc.title F-18-Fluoride PET/CT and Tc-99m-MDP SPECT/CT can detect bone cancer at early stage in rodents
dc.type article
dc.rights.holder Copyright PERGAMON-ELSEVIER SCIENCE LTD
dc.description.group LIM/24
dc.description.group LIM/43
dc.identifier.doi 10.1016/j.lfs.2018.05.030
dc.identifier.pmid 29778807
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author FARIA, Daniele de P.:HC:ICESP
hcfmusp.author GARCEZ, Alexandre T.:HC:ICESP
hcfmusp.author CHAMMAS, Roger:FM:MDR
hcfmusp.author.external · ALVES, Christiano R. R.:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil; Harvard Med Sch, Joslin Diabet Ctr, Boston, MA USA
· CARNEIRO, Camila de G.:Univ Sao Paulo, Dept Radiol & Oncol, Fac Med, Sao Paulo, Brazil
· GUTIERREZ, Vanessa P.:Butantan Inst, Lab Pain & Signaling, Sao Paulo, Brazil
· NEVES, Willian das:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
· ALMEIDA, Ney R. de:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
· CURY, Yara:Butantan Inst, Lab Pain & Signaling, Sao Paulo, Brazil
· BRUM, Patricia C.:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000434294900004
hcfmusp.origem.id 2-s2.0-85048718879
hcfmusp.publisher.city OXFORD
hcfmusp.publisher.country ENGLAND
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dc.description.index MEDLINE
dc.identifier.eissn 1879-0631
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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