Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MARTINS, Toni Ricardo FMUSP-HC
LONGATTO-FILHO, Adhemar FMUSP-HC
COHEN, Diane
VISCONDI, Juliana Yukari Kodaira FMUSP-HC
FUZA, Luiz Mario FMUSP-HC
CURY, Lise
VILLA, Luisa Lina FMUSP-HC
LEVI, Jose Eduardo FMUSP-HC
ELUF-NETO, Jose FMUSP-HC
dc.date.issued 2018
dc.identifier.citation AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.149, n.4, p.316-323, 2018
dc.identifier.issn 0002-9173
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/26923
dc.description.abstract Objectives: This study aimed to evaluate the influence of prior knowledge of human papillomavirus (HPV) status in cervical cytopathology readings. Methods: Participants comprised 2,376 women who underwent parallel cytology and HPV-DNA testing. Smears were read twice by the same team, first with previous knowledge of HPV-DNA status. Results: Overall, 239 (10.2%) smears had their cytology classification altered by the HPV-informed review. Cytology readings with prior knowledge of the HPV status revealed 10.5% of abnormal smears (atypical squamous cells of undetermined significance or higher), while without prior knowledge, this rate dropped to 7.6%. When HPV status was informed, a significant increase in all categories of altered smears was observed. Cytology with prior knowledge of HPV status detected more cervical intraepithelial neoplasia grade 2 or higher (CIN 2+) compared with blinded: 86.7% vs 60.0%. Conclusions: Our data indicate that cytology interpreted with prior knowledge of the HPV status provides higher sensitivity for CIN 2+ lesions while marginally reducing the overall specificity compared with HPV status blinded cytology.
dc.description.sponsorship · Instituto Nacional de Ciencia e Tecnologia das Doencas do Papilomavirus Humano INCT-HPV (National Institute of Science and Technology of the Diseases Associated to the Papillomavirus) through CNPq [573799/2008-3]
· Instituto Nacional de Ciencia e Tecnologia das Doencas do Papilomavirus Humano INCT-HPV (National Institute of Science and Technology of the Diseases Associated to the Papillomavirus) through FAPESP [2008/57889-1]
dc.language.iso eng
dc.publisher OXFORD UNIV PRESS INC
dc.relation.ispartof American Journal of Clinical Pathology
dc.rights restrictedAccess
dc.subject Cervical cytology; Screening; HPV-DNA; Papanicolaou test; Cervical cancer
dc.subject.other liquid-based cytology; cervical-cancer; pap test; triage; athena; women
dc.title Influence of Prior Knowledge of Human Papillomavirus Status on the Performance of Cytology Screening
dc.type article
dc.rights.holder Copyright OXFORD UNIV PRESS INC
dc.description.group LIM/52
dc.description.group LIM/14
dc.description.group LIM/24
dc.description.group LIM/38
dc.identifier.doi 10.1093/AJCP/AQX163
dc.identifier.pmid 29471316
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author MARTINS, Toni Ricardo:HC:LIM/52
hcfmusp.author LONGATTO-FILHO, Adhemar:IMT:
hcfmusp.author VISCONDI, Juliana Yukari Kodaira:FM:
hcfmusp.author FUZA, Luiz Mario:IMT:
hcfmusp.author VILLA, Luisa Lina:FM:MDR
hcfmusp.author LEVI, Jose Eduardo:IMT:
hcfmusp.author ELUF-NETO, Jose:FM:MPR
hcfmusp.author.external · COHEN, Diane:Fundacao Oncoctr Sao Paulo, Oscar Freire St 2396, BR-05409012 Sao Paulo, SP, Brazil
· CURY, Lise:Fundacao Oncoctr Sao Paulo, Oscar Freire St 2396, BR-05409012 Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000429453100005
hcfmusp.origem.id 2-s2.0-85050764430
hcfmusp.publisher.city CARY
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1943-7722
hcfmusp.citation.scopus 0
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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