Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease: Paracoccidioides brasiliensis or Paracoccidioides lutzii?

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author BUCCHERI, Renata FMUSP-HC
MORAIS, Vanessa dos Santos FMUSP-HC
KAMIKAWA, Camila Mika
VIDAL, Monica Scarpelli Martinelli FMUSP-HC
NAVES, Gabriel FMUSP-HC
NEGRO, Gilda Maria Barbaro Del FMUSP-HC
VICENTINI, Adriana Pardini
BENARD, Gil FMUSP-HC
dc.date.issued 2018
dc.identifier.citation AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, v.98, n.4, p.1082-1085, 2018
dc.identifier.issn 0002-9637
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/26925
dc.description.abstract Negative results inserological routine screening of patients with microbiologically proven Paracoccidioidomycosis (PCM) are occasionally reported. Failure in detecting anti-Paracoccidioides antibodies has been ascribed to factors either related to serological techniques or to the status of the host immune reactivity. Recently, this issue has been renewed by the recognition that the Paracoccidioides genera comprises two species, lutzii and brasiliensis, which have distinct antigenic profiles and, therefore, may elicit different host antibody responses. We describe a patient with the acute form PCM due to Paracoccidioides brasiliensis with negative results on two reference centers' routine screening for P. brasiliensis antibodies, but positive results with Paracoccidioides lutzii antigens. The present case report suggests that antibodies elicited during P. brasiliensis infection recognize antigenic fractions shared by both species, highlighting the difficulties in distinguishing the two infections by means of the currently available routine serological assays.
dc.language.iso eng
dc.publisher AMER SOC TROP MED & HYGIENE
dc.relation.ispartof American Journal of Tropical Medicine and Hygiene
dc.rights restrictedAccess
dc.subject.other immunodiffusion test; sera; antibodies; gp43; pathogenesis; reactivity; isoforms; epitopes; antigen; brazil
dc.title Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease: Paracoccidioides brasiliensis or Paracoccidioides lutzii?
dc.type article
dc.rights.holder Copyright AMER SOC TROP MED & HYGIENE
dc.description.group LIM/53
dc.description.group LIM/56
dc.identifier.doi 10.4269/ajtmh.17-0812
dc.identifier.pmid 29405111
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author BUCCHERI, Renata:FM:
hcfmusp.author MORAIS, Vanessa dos Santos:HC:LIM/53
hcfmusp.author VIDAL, Monica Scarpelli Martinelli:IMT:SCMM-83
hcfmusp.author NAVES, Gabriel:FM:
hcfmusp.author NEGRO, Gilda Maria Barbaro Del:HC:LIM/53
hcfmusp.author BENARD, Gil:FM:MDT
hcfmusp.author.external · KAMIKAWA, Camila Mika:Adolfo Lutz Inst, Immunol Ctr, Sao Paulo, Brazil
· VICENTINI, Adriana Pardini:Adolfo Lutz Inst, Immunol Ctr, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000430958200020
hcfmusp.origem.id 2-s2.0-85045474603
hcfmusp.publisher.city MCLEAN
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1476-1645
hcfmusp.citation.scopus 1
hcfmusp.citation.wos 2
hcfmusp.affiliation.country Brasil


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