Acute exposure to diesel and sewage biodiesel exhaust causes pulmonary and systemic inflammation in mice
Carregando...
Citações na Scopus
35
Tipo de produção
article
Data de publicação
2018
Editora
ELSEVIER SCIENCE BV
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
CAVALHEIRO, Guilherme Franco
OLIVEIRA, Luciano Basto
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
SCIENCE OF THE TOTAL ENVIRONMENT, v.628-629, p.1223-1233, 2018
Resumo
Biodiesel is a renewable energy source that reduces particle emission, but few studies have assessed its effects. To assess the effects of acute inhalation of two doses (600 and 1200 mu g/m(3)) of diesel (DE) and biodiesel (BD) fuels on the inflammatory pulmonary and systemic profile of mice. Animals were exposed for 2 h in an inhalation chamber inside the Container Laboratory for Fuels. Heart rate, heart rate variability (HRV) and blood pressure were determined 30 min after exposure. After 24 h. we analyzed the lung inflammation using bronchoalveolar lavage fluid (BALF); neutrophil and macrophage quantification in the lung parenchyma was performed, and blood and bone marrow biomarkers as well as receptor of endothelin-A (ET-Ar), receptor of endothelin-B (ET-Br), vascular cell adhesion molecule 1 (VCAM-1), inducible nitric oxide synthase (iNOs) and isoprostane (ISO) levels in the pulmonary vessels and bronchial epithelium were evaluated. HRV increased for BD600, D600 and D1200 compared to filtered air (FA). Both fuels (DE and BD) produced alterations in red blood cells independent of the dose. BALI from the BD600 and BD1200 groups showed an increase in neutrophils compared to those of the FA group. Numeric density of the polyrnorphonuclear and mononudear cells was elevated with BD600 compared to FA. In the peribronchiolar vessels, there was an increase in ET-Ar and ET-Br expression following BD600 compared to IA; and there was a reduction in the iNOs expression for BD1200 and the VCAM-1 for D1200 compared to FA. In the bronchial epithelium, there was an increase in ETAr at BD600, ET-Br at two doses (600 and 1200 mu g/m(3)) of DE and BD, iNOs at D600 and VCAM-1 at BD1200 and D600; all groups were compared to the FA group. Acute exposure to DE and BD derived from sewage methyl esters triggered pulmonary and cardiovascular inflammatory alterations in mice.
Palavras-chave
Diesel, Biodiesel, Particulate matter, Toxicity, Inflammation, Heart rate variability
Referências
- Andrade MD, 2012, AIR QUAL ATMOS HLTH, V5, P79, DOI 10.1007/s11869-010-0104-5
- Bhavaraju L, 2014, CHEMOSPHERE, V104, P126, DOI 10.1016/j.chemosphere.2013.10.080
- Bhavsar TM, 2008, EXP LUNG RES, V34, P707, DOI 10.1080/01902140802389701
- Brito JM, 2010, TOXICOL SCI, V116, P67, DOI 10.1093/toxsci/kfq107
- Bunger J, 2012, CRIT REV TOXICOL, V42, P732, DOI 10.3109/10408444.2012.710194
- Campen MJ, 2005, TOXICOL SCI, V88, P95, DOI 10.1093/toxsci/kfi283
- Carll AP, 2012, TOXICOL SCI, V128, P490, DOI 10.1093/toxsci/kfs162
- Channell MM, 2012, TOXICOL SCI, V127, P179, DOI 10.1093/toxsci/kfs084
- de Brito JM, 2014, J APPL PHYSIOL, V117, P492, DOI 10.1152/japplphysiol.00156.2014
- de Miranda RM, 2012, AIR QUAL ATMOS HLTH, V5, P63, DOI 10.1007/s11869-010-0124-1
- Demirbas A, 2017, ENERG SOURCE PART B, V12, P351, DOI 10.1080/15567249.2015.1135204
- EPA, 2016, INT SCI ASS OX NITR
- EPA, 2002, 118 EPA, P118
- Farraj AK, 2015, INHAL TOXICOL, V27, P564, DOI 10.3109/08958378.2015.1057884
- Fernandes LB, 1996, BRIT J PHARMACOL, V118, P1873, DOI 10.1111/j.1476-5381.1996.tb15617.x
- Finsnes F, 2001, AM J PHYSIOL-LUNG C, V280, pL659
- Fukagawa NK, 2013, ENVIRON SCI TECHNOL, V47, P12496, DOI 10.1021/es403146c
- Gangwar J, 2011, INHAL TOXICOL, V23, P449, DOI 10.3109/08958378.2011.582189
- Hazari MS, 2011, ENVIRON HEALTH PERSP, V119, P951, DOI 10.1289/ehp.1003200
- Hazari MS, 2009, TOXICOL SCI, V112, P532, DOI 10.1093/toxsci/kfp214
- Hemmingsen JG, 2011, ENVIRON SCI TECHNOL, V45, P8545, DOI 10.1021/es200956p
- HENRY PJ, 1995, BRIT J PHARMACOL, V114, P563, DOI 10.1111/j.1476-5381.1995.tb17176.x
- IEA, 2016, WORLD EN OUTL 2016
- Kafoury Ramzi M, 2005, Int J Environ Res Public Health, V2, P403, DOI 10.3390/ijerph2005030004
- Karthikeyan S, 2013, TOXICOL SCI, V135, P437, DOI 10.1093/toxsci/kft162
- Lamb CM, 2012, TOXICOL SCI, V125, P558, DOI 10.1093/toxsci/kfr296
- Larcombe AN, 2015, RESPIROLOGY, V20, P1034, DOI 10.1111/resp.12587
- Larcombe AN, 2014, INHAL TOXICOL, V26, P409, DOI 10.3109/08958378.2014.909910
- Lewis JA, 2007, ENVIRON HEALTH PERSP, V115, P756, DOI 10.1289/ehp.9745
- Lowe GDO, 2006, BRIT J HAEMATOL, V133, P232, DOI 10.1111/j.1365-2141.2006.06021.x
- Medeiros N, 2004, ENVIRON RES, V95, P62, DOI 10.1016/j.envres.2003.07.007
- Mullins BJ, 2016, ENVIRON TOXICOL, V31, P44, DOI 10.1002/tox.22020
- Mutlu E, 2015, INHAL TOXICOL, V27, P515, DOI 10.3109/08958378.2015.1076910
- Nemmar A, 2007, AM J PHYSIOL-LUNG C, V292, pL664, DOI 10.1152/ajplung.00240.2006
- Nemmar A, 2013, AM J PHYSIOL-HEART C, V305, pH740, DOI 10.1152/ajpheart.00200.2013
- Nemmar A, 2011, BRIT J PHARMACOL, V164, P1871, DOI 10.1111/j.1476-5381.2011.01442.x
- Nemmar A, 2009, TOXICOLOGY, V262, P50, DOI 10.1016/j.tox.2009.05.009
- Carvalho ALN, 2011, J ETHNOPHARMACOL, V135, P730, DOI 10.1016/j.jep.2011.04.002
- Olkiewicz M, 2012, PROCEDIA ENGINEER, V42, P634, DOI 10.1016/j.proeng.2012.07.456
- Pedroso L. R. M., 2012, APROVEITAMENTO ENERG
- Polikepahad S, 2006, AM J VET RES, V67, P348, DOI 10.2460/ajvr.67.2.348
- Saxena QB, 2003, TOXICOL LETT, V143, P317, DOI 10.1016/S0378-4274(03)00192-9
- Seriani R, 2015, ENVIRON TOXICOL, V30, P1297, DOI 10.1002/tox.22000
- Shvedova AA, 2013, J TOXICOL ENV HEAL A, V76, P907, DOI 10.1080/15287394.2013.825217
- Toledo AC, 2013, BRIT J PHARMACOL, V168, P1736, DOI 10.1111/bph.12062
- Tornqvist H, 2007, AM J RESP CRIT CARE, V176, P395, DOI 10.1164/rccm.200606-872OC
- van Eeden SF, 2001, AM J RESP CRIT CARE, V164, P826, DOI 10.1164/ajrccm.164.5.2010160
- WHO, 2005, AIR QUAL GUID PART M
- Yanamala N, 2013, TOXICOL APPL PHARM, V272, P373, DOI 10.1016/j.taap.2013.07.006
- Zhang J, 2010, TOXICOL PATHOL, V38, P856, DOI 10.1177/0192623310378866
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/03
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - ODS/07
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/03
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - ODS/07