Pathology and pathogenesis of human leptospirosis: a commented review

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author BRITO, Thales De FMUSP-HC
SILVA, Ana Maria Goncalves da FMUSP-HC
ABREU, Patricia Antonia Estima
dc.date.issued 2018
dc.identifier.citation REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.60, article ID UNSP e23, 10p, 2018
dc.identifier.issn 0036-4665
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/27055
dc.description.abstract Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil contaminated with urine from infected animals. Leptospires enter the body by penetrating mucous membranes or skin abrasions and disseminate through the hematogenic route. In humans, leptospirosis may cause a wide spectrum of symptoms. Most cases have a biphasic clinical presentation, which begins with the septicemic phase followed by immune manifestations. The severe forms of the disease may be life threatening with multisystem damage including renal failure, hepatic dysfunction, vascular damage, pulmonary hemorrhage and muscle lesions. In this review, we present and discuss the pathogenesis of the human disease and the mechanisms of cell membrane injuries, which occur mainly due to the presence of leptospires and/or their antigen/s in the host tissues.
dc.language.iso eng
dc.publisher INST MEDICINA TROPICAL SAO PAULO
dc.relation.ispartof Revista do Instituto de Medicina Tropical de Sao Paulo
dc.rights openAccess
dc.subject Leptospira; Leptospirosis; Cadherins; Weil syndrome; Acute liver and kidney injury
dc.subject.other interrogans serovar copenhageni; acute kidney injury; electron-microscopy; weils-disease; guinea-pig; ve-cadherin; liver; antigen; damage; diagnosis
dc.title Pathology and pathogenesis of human leptospirosis: a commented review
dc.type article
dc.rights.holder Copyright INST MEDICINA TROPICAL SAO PAULO
dc.description.group LIM/06
dc.identifier.doi 10.1590/S1678-9946201860023
dc.identifier.pmid 29846473
dc.type.category review
dc.type.version publishedVersion
hcfmusp.author BRITO, Thales De:FM:MPT
hcfmusp.author SILVA, Ana Maria Goncalves da:IMT:SCHEL-83
hcfmusp.author.external · ABREU, Patricia Antonia Estima:Inst Butantan, Lab Bacteriol, Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000433568800002
hcfmusp.origem.id 2-s2.0-85047815546
hcfmusp.origem.id SCIELO:S0036-46652018005000400
hcfmusp.publisher.city SAO PAULO
hcfmusp.publisher.country BRAZIL
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dc.description.index MEDLINE
dc.identifier.eissn 1678-9946
hcfmusp.citation.scopus 2
hcfmusp.citation.wos 2
hcfmusp.affiliation.country Brasil


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