Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/27121
Title: | Treg and NK cells related cytokines are associated with deep rectosigmoid endometriosis and clinical symptoms related to the disease |
Authors: | GUEUVOGHLANIAN-SILVA, Barbara Yasmin; BELLELIS, Patrick; BARBEIRO, Denise Frediani; HERNANDES, Camila; PODGAEC, Sergio |
Citation: | JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v.126, p.32-38, 2018 |
Abstract: | The aim of this study was to evaluate Treg and NK cells related cytokines in deep infiltrating endometriosis lesions and its relationship with clinical symptoms of the disease. mRNA expression of Transforming Growth Factor Beta (TGFB), Interleukin (IL)10, Interferon Gamma (IFNG), IL7, and IL15 was analyzed by Real-Time PCR in eutopic endometrium and rectosigmoid lesions from 11 women with deep infiltrating endometriosis and in eutopic endometrium from 11 healthy women. IL10, IFNG, and IL7 expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from women with endometriosis. IL10 and TGFB expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from healthy women. In addition, TGFB and IL15 levels correlated positively with deep dyspareunia and cyclic dyschezia, respectively, while IL7 levels correlated negatively with dysmenorrhea. Deep infiltrating rectosigmoid endometriosis displays alterations in Treg and NK cells related cytokine, and TGFB, IL7 and IL15 expression is related with dyspareunia, dysmenorrhea and cyclic dyschezia, respectively, in patients with the disease. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/51 Artigos e Materiais de Revistas Científicas - LIM/58 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_GUEUVOGHLANIAN-SILVA_Treg_and_NK_cells_related_cytokines_are_associated_2018.PDF Restricted Access | publishedVersion (English) | 522.32 kB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.