Hypercholesterolemic diet worst left ventricular function evaluated by echocardiography in rats subjected to an experimental infarct model

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author DOURADO, Paulo M. FMUSP-HC
TSUTSUI, Jeane M. FMUSP-HC
CASELLA FILHO, Antonio FMUSP-HC
LANDIM, Mauricio B.
GALVAO, Tatiana F.
AIELLO, Vera D. FMUSP-HC
LUZ, Protasio Da FMUSP-HC
MATHIAS JR., Wilson FMUSP-HC
CHAGAS, Antonio C. FMUSP-HC
dc.date.issued 2012
dc.identifier.citation CIRCULATION, v.125, n.19, p.E822-E822, 2012
dc.identifier.issn 0009-7322
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2789
dc.description.abstract Introduction: A better comprehension of the hypercholesterolemic diet role in the set of acute myocardial infarct is fundamental. Objectives: Evaluation of the role of hypercholesterolemic diet in the determination of the hemodynamics patterns by echocardiography. Methods: Sixty three anesthetized rats were subjected to occlusion of the left anterior descending (LAD) coronary artery and divided in six groups: G1–just normal diet (ND); G2–ND and treatment with rosuvastatim for 30 days began after infarct and G3–ND and 30 days previously to infarct treated with rosuvastatim until 30 days after it; G4 –just hypercholesterolemic diet (HD); G5–HD and treatment with rosuvastatim for 30 days began after infarct and G6 –HD and 30 days previously to infarct treated with rosuvastatim until 30 days after it. Echocardiography was performed using bidimensional image in the paraesternal long axis. The planimetry of the left ventricle areas in the end of the diastole (LVEDA) and systole (LVESA) were realized before the infarct (pre) and 30 days after the infarct (post) . A p value<0.05 was considered significant. Conclusion: The hypercholesterolemic diet worst the hemodynamics parameters–LVEDA and LVESA - in comparison with the normocholesterolemic group treated with rosuvastatim.
dc.language.iso eng
dc.publisher LIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartof Circulation
dc.rights restrictedAccess
dc.title Hypercholesterolemic diet worst left ventricular function evaluated by echocardiography in rats subjected to an experimental infarct model
dc.type conferenceObject
dc.rights.holder Copyright LIPPINCOTT WILLIAMS & WILKINS
dc.description.conferencedate APR 18-21, 2012
dc.description.conferencelocal Dubai, U ARAB EMIRATES
dc.description.conferencename World Congress of Cardiology Scientific Sessions 2012
dc.type.category meeting abstract
dc.type.version publishedVersion
hcfmusp.author DOURADO, Paulo M.:HC:INCOR
hcfmusp.author TSUTSUI, Jeane M.:HC:INCOR
hcfmusp.author CASELLA FILHO, Antonio:FM:
hcfmusp.author AIELLO, Vera D.:HC:INCOR
hcfmusp.author LUZ, Protasio Da:FM:MCP
hcfmusp.author MATHIAS JR., Wilson:HC:INCOR
hcfmusp.author CHAGAS, Antonio C.:HC:INCOR
hcfmusp.author.external · LANDIM, Mauricio B.:Univ Sao Paulo, Heart Inst Incor, Sao Paulo, Brazil
· GALVAO, Tatiana F.:Univ Sao Paulo, Heart Inst Incor, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000307009201141
hcfmusp.publisher.city PHILADELPHIA
hcfmusp.publisher.country USA
dc.description.index MEDLINE
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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