Does the urinary tract infection caused by carbapenem-resistant Gram-negative bacilli impact the outcome of kidney transplant recipients?

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art_FREIRE_Does_the_urinary_tract_infection_caused_by_carbapenemresistant_2018.PDF (448.42 KB)
Citações na Scopus
14
Tipo de produção
article
Data de publicação
2018
Editora
WILEY
DOI
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Scopus
Web of Science
PubMed
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Citação
TRANSPLANT INFECTIOUS DISEASE, v.20, n.4, article ID e12923, 11p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The incidence of urinary tract infection (UTI) after kidney transplantation (KT) caused by multidrug-resistant (MDR) bacteria is growing. The aim of this study was to analyze the impact of UTI caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) in the survival of graft and recipients following KT. This was a retrospective cohort study involving patients who underwent KT between 2013 and 2016. Patients were followed since the day of the KT until loss of graft, death or end of the follow-up period (31th December 2016). The outcomes measured were UTI by MDR following KT and graft and patient survival. Analyses were performed using Cox regression; for the graft and patient survival analysis, we used a propensity score for UTI by CR-GNB to matching a control group. UTI was diagnosed in 178 (23.9%) of 781 patients, who developed 352 UTI episodes. 44.6% of the UTI cases were caused by MDR bacteria. Identified risk factors for UTI by MDR bacteria were DM, urologic disease as the cause of end-stage renal failure, insertion of ureteral stent, carbapenem use, and delayed graft function (DGF). Risk factors for death during the follow-up period were female gender, patients over 60years old at the time of KT, DM, body mass index over 31.8, UTI caused by CR-GNB. In conclusion, UTIs caused by CR-GNB have great impact on patients' survival after KT.
Palavras-chave
carbapenem resistance, diabetes mellitus, kidney transplantation, Klebsiella pneumoniae, mortality, multidrug resistance, Pseudomonas aeruginosa, risk factor, urinary tract infection
URI
https://observatorio.fm.usp.br/handle/OPI/27960
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/47
Artigos e Materiais de Revistas Científicas - LIM/55
Artigos e Materiais de Revistas Científicas - ODS/03