Matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms promote increase and remodeling of the collagen III and V in posterior tibial tendinopathy

Imagem de Miniatura
Arquivos
art_DINIZ-FERNANDES_Matrix_metalloproteinase1_MMP1_and_MMP8_gene_polymorphisms_promote_2018.PDF (10.07 MB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
F HERNANDEZ
Autores
SANTOS, Maria Cristina
MAFFULLI, Nicola
Citação
HISTOLOGY AND HISTOPATHOLOGY, v.33, n.9, p.929-936, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Posterior tibial tendinopathy (PTT) can lead to acquired flatfoot in adults. Many patients develop PTT without any identifiable risk factors. Molecular changes in extracellular matrix (ECM) and matrix metalloproteinase (MMP) polymorphism may influence the risk of developing PTT. We aim to investigate the association between matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms with changes in collagen I, III and V in PTT. A case-control study with 22 patients and 5 controls was performed. The MMP-1 (2G/2G) and MMP-8 (T/T) genotypes were determined by PCR-restriction fragment length polymorphism. Tendon specimens were evaluated by a histologic semiquantitative score, immunofluorescence and histomorphometry for collagen I, III and V. Tendon specimens from PTT demonstrated marked distortion of the architecture with necrosis, large basophilic areas with disruption of the normal linear orientation of collagen bundles, infiltration of inflammatory cells, dystrophic calcification and ossification. Under immunofluorescence, PTT tendon specimens showed weak green fluorescence and diffuse distribution of collagen I fibers, but strong fluorescence of collagen III and V. The collagen I fibers were significantly decreased whereas an increase of collagen III and V were found in PTT compared to control groups. In addition, PTT group presented a significant association with MMP-1 and MMP-8 gene polymorphisms. Patients with PTT matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms presented an increase of the collagen III and V ratio, suggesting that the higher proportion in degenerated tendons could contribute to a decrease in the mechanical resistance of the tissue. Still, functional and association studies are needed to elucidate evident roles of MMPs in PTT.
Palavras-chave
Tendinopathy, Genetic, Extracellular matrix, Metalloproteinase, Collagen
URI
https://observatorio.fm.usp.br/handle/OPI/28177
Referências
  1. Aidar Marisi, 2007, Braz. Dent. J., V18, P148, DOI 10.1590/S0103-64402007000200012
  2. Alfredson H, 2005, SCAND J MED SCI SPOR, V15, P252, DOI 10.1111/j.1600-0838.2005.00466.x
  3. Bank RA, 1999, ANN RHEUM DIS, V58, P35, DOI 10.1136/ard.58.1.35
  4. Baroneza JE, 2014, GENE, V547, P334, DOI 10.1016/j.gene.2014.07.001
  5. Corps AN, 2012, ANN RHEUM DIS, V71, P746, DOI 10.1136/annrheumdis-2011-200391
  6. de Mos M, 2007, AM J SPORT MED, V35, P1549, DOI 10.1177/0363546507301885
  7. Del Buono Angelo, 2013, Muscles Ligaments Tendons J, V3, P51, DOI 10.11138/mltj/2013.3.1.051
  8. Deland JT, 2005, FOOT ANKLE INT, V26, P427, DOI 10.1177/107110070502600601
  9. Dyal CM, 1997, FOOT ANKLE INT, V18, P85, DOI 10.1177/107110079701800208
  10. Fearon A, 2014, J SCI MED SPORT, V17, P346, DOI 10.1016/j.jsams.2013.07.008
  11. FUNK DA, 1986, J BONE JOINT SURG AM, V68A, P95, DOI 10.2106/00004623-198668010-00012
  12. GALIS ZS, 1994, J CLIN INVEST, V94, P2493, DOI 10.1172/JCI117619
  13. Godoy-Santos A, 2014, SCAND J MED SCI SPOR, V24, P220, DOI 10.1111/j.1600-0838.2012.01469.x
  14. Godoy-Santos A, 2013, J ORTHOP RES, V31, P1103, DOI 10.1002/jor.22321
  15. Goncalves-Neto J, 2002, JOINT BONE SPINE, V69, P189, DOI 10.1016/S1297-319X(02)00369-X
  16. Ireland D, 2001, MATRIX BIOL, V20, P159, DOI 10.1016/S0945-053X(01)00128-7
  17. JOHNSON KA, 1983, CLIN ORTHOP RELAT R, P140
  18. JOHNSON KA, 1989, CLIN ORTHOP RELAT R, P196
  19. Kannus P, 2000, SCAND J MED SCI SPOR, V10, P312, DOI 10.1034/j.1600-0838.2000.010006312.x
  20. Karousou E, 2008, CLIN ORTHOP RELAT R, V466, P1577, DOI 10.1007/s11999-008-0255-y
  21. Kerrigan J J, 2000, J Orthod, V27, P227
  22. Kohls-Gatzoulis J, 2009, Foot Ankle Surg, V15, P75, DOI 10.1016/j.fas.2008.08.003
  23. Lakemeier S, 2011, KNEE SURG SPORT TR A, V19, P1760, DOI 10.1007/s00167-010-1367-y
  24. Maffulli N, 2003, CLIN SPORT MED, V22, P675, DOI 10.1016/S0278-5919(03)00004-8
  25. Maffulli N, 2000, AM J SPORT MED, V28, P857, DOI 10.1177/03635465000280061401
  26. Mokone GG, 2006, SCAND J MED SCI SPOR, V16, P19, DOI 10.1111/j.1600-0838.2005.00439.x
  27. Mokone GG, 2005, AM J SPORT MED, V33, P1016, DOI 10.1177/0363546504271986
  28. Mosier SM, 1998, FOOT ANKLE INT, V19, P520, DOI 10.1177/107110079801900803
  29. Myerson MS, 1996, J BONE JOINT SURG AM, V78A, P780, DOI 10.2106/00004623-199605000-00020
  30. Pomeroy GC, 1999, J BONE JOINT SURG AM, V81A, P1173, DOI 10.2106/00004623-199908000-00014
  31. Posthumus M, 2010, RHEUMATOLOGY, V49, P2090, DOI 10.1093/rheumatology/keq072
  32. Posthumus M, 2009, J SCI MED SPORT, V12, P184, DOI 10.1016/j.jsams.2007.12.006
  33. Raleigh SM, 2009, BRIT J SPORT MED, V43, P514, DOI 10.1136/bjsm.2008.053892
  34. Reuther KE, 2013, J BIOMECH, V46, P1818, DOI 10.1016/j.jbiomech.2013.05.007
  35. Riley G, 2004, RHEUMATOLOGY, V43, P131, DOI 10.1093/rheumatology/keg448
  36. Riley GP, 2005, SCAND J MED SCI SPOR, V15, P241, DOI 10.1111/j.1600-0838.2005.00456.x
  37. Riley GP, 2002, MATRIX BIOL, V21, P185, DOI 10.1016/S0945-053X(01)00196-2
  38. Satomi E, 2008, CLINICS, V63, P9, DOI 10.1590/S1807-59322008000100003
  39. Tasci AI, 2008, BJU INT, V101, P503, DOI 10.1111/j.1464-410X.2007.07315.x
  40. TSUZAKI M, 1993, CONNECT TISSUE RES, V29, P141, DOI 10.3109/03008209309014241
  41. Waggett AD, 1998, MATRIX BIOL, V16, P457, DOI 10.1016/S0945-053X(98)90017-8
  42. Xu YH, 2008, CLIN ORTHOP RELAT R, V466, P1528, DOI 10.1007/s11999-008-0286-4

Coleções
Artigos e Materiais de Revistas Científicas - FM/MOT
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/02
Carregar mais