Histopathology of 460 liver allografts removed at retransplantation: A shift in disease patterns over 27 years

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art_SOUZA_Histopathology_of_460_liver_allografts_removed_at_retransplantation_2018.PDF (755.13 KB)
Citações na Scopus
17
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
SOUZA, Lara Neves
SANCHEZ-FUEYO, Alberto
RELA, Mohamed
DHAWAN, Anil
O'GRADY, John
HEATON, Nigel
QUAGLIA, Alberto
Citação
CLINICAL TRANSPLANTATION, v.32, n.4, article ID e13227, 7p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background and aim: Approximately 10%-19% of liver transplant recipients develop irreversible graft failure requiring retransplantation. We reviewed the histology of failed grafts removed at retransplantation in our center over 27 years. Methods: Two hundred and seventy-six adults and 118 children underwent retransplantation from 1987 to 2014, receiving 321 and 139 liver grafts, respectively. We analyzed graft histology, recipient demographics, indications and time interval to retransplantation. We divided retransplantation in 3 eras: A (1987-1994), B (1995-2001), and C (2002-2014). Results: A total of 3298 adult and 938 pediatric primary liver transplants were conducted in our center, and 8.4% of adults and 12.6% of children experienced retransplantation. Considering the changes throughout the eras, the proportion of chronic rejection declined, while that of unexplained chronic fibrosing hepatitis increased steadily, representing the main reason for retransplantation conducted >10 years after primary transplant in children, and second in adults in the most recent era. This chronic hepatitis of the graft might correspond to a slowly evolving form of rejection, possibly with a humoral component, associated with progressive graft fibrosis and eventually failure. Conclusions: We observed a shift in histopathology of failed liver grafts, with increasing relevance of chronic idiopathic hepatitis associated with progressive fibrosis and graft failure.
Palavras-chave
chronic hepatitis, fibrosis, graft rejection, graft survival, histology, liver transplantation
URI
https://observatorio.fm.usp.br/handle/OPI/28365
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - ODS/03