C-myc expression in dysplasias and carcinomas developed in the tongue from galectin-3-deficient and wild-type mice challenged by 4NQO

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author GONCALVES, G. J. M.
RAMOS, W. A.
CHAMMAS, R. FMUSP-HC
LOYOLA, A. M.
CARDOSO, S. V.
FARIA, P. R.
dc.date.issued 2012
dc.identifier.citation HISTOPATHOLOGY, v.61, suppl.1, Special Issue, p.130-131, 2012
dc.identifier.issn 0309-0167
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2843
dc.description.abstract Introduction: Oral squamous cell carcinoma is a common world-wide malignancy and its pathogenesis may be related to Wnt-protein expression and galectin-3. Likewise, the oncogenic role of galectin-3 (GAL3) can be attributed to its involvement in the Wnt signaling, especially by enhancing c-myc expression. However, no study has hitherto shown whether GAL3 interferes in the expression of this protein during oral carcinogenesis. This study reports c-myc expression in dysplasias and carcinomas developed induced in the tongue of galectin-3 deficient (GAL3)/)) and wild-type (GAL3+/+) mice. Material and Methods: Of 60 GAL3)/) and GAL3 +/+ mice were treated with 4NQO for 16 weeks and killed at week 16 and week 32. Tongues were removed and embedded in paraffin. Sections were stained with hematoxylin-eosin to diagnose dysplasias and carcinomas. An immunohistochemical assay was applied to detectc-myc in these lesions. Results: Oral carcinogenesis occurred in both groups (P > 0.05). C-myc expression was mainly observed in the cytoplasm of dysplastic and tumor cells. The intensity varied from weak, moderate to intense in both dysplasias and carcinomas. The mean of c-myc positive cells in dysplasias and carcinomas from GAL3 +/+ mice was 1.43 ± 2.05 and 1.2 ± 1.62 respectively. In GAL3)/) mice, the mean was 3.49 ± 3.20 in dysplastic lesions and 2.95 ± 2.30 in carcinomas. All differences showed to be statistically significant (P < 0.05). Conclusion: Our results revealed that the absence of GAL3 altered the c-myc expression in dysplasias and carcinomas in GAL3)/) mice when compared no alteration of c-myc expression in those lesions in GAL3 +/+ mice (FAPEMIG).
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Histopathology
dc.rights restrictedAccess
dc.title C-myc expression in dysplasias and carcinomas developed in the tongue from galectin-3-deficient and wild-type mice challenged by 4NQO
dc.type conferenceObject
dc.rights.holder Copyright WILEY-BLACKWELL
dc.description.conferencedate SEP 30-OCT 05, 2012
dc.description.conferencelocal Cape Town, SOUTH AFRICA
dc.description.conferencename 29th Congress of the International-Academy-of-Pathology
dc.description.group LIM/24
dc.type.category meeting abstract
dc.type.version publishedVersion
hcfmusp.author CHAMMAS, R.:FM:MDR
hcfmusp.author.external · GONCALVES, G. J. M.:Univ Fed Uberlandia, Fac Med, Uberlandia, MG, Brazil
· RAMOS, W. A.:Univ Fed Uberlandia, Fac Med, Uberlandia, MG, Brazil
· LOYOLA, A. M.:Univ Fed Uberlandia, Fac Odontol, Uberlandia, MG, Brazil
· CARDOSO, S. V.:Univ Fed Uberlandia, Fac Odontol, Uberlandia, MG, Brazil
· FARIA, P. R.:Univ Fed Uberlandia, Inst Ciencias Biomed, Uberlandia, MG, Brazil
hcfmusp.origem.id WOS:000308126900378
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
dc.description.index MEDLINE
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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