Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women

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art_TOBIAS_Circulating_BranchedChain_Amino_Acids_and_Incident_Cardiovascular_Disease_2018.PDF (173.33 KB)
Citações na Scopus
149
Tipo de produção
article
Data de publicação
2018
Editora
LIPPINCOTT WILLIAMS & WILKINS
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
TOBIAS, Deirdre K.
LAWLER, Patrick R.
DEMLER, Olga V.
RIDKER, Paul M.
MANSON, JoAnn E.
CHENG, Susan
MORA, Samia
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
CIRCULATION-GENOMIC AND PRECISION MEDICINE, v.11, n.4, article ID UNSP e002157, 9p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BACKGROUND: Circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are strong predictors of type 2 diabetes mellitus (T2D), but their association with cardiovascular disease (CVD) is uncertain. We hypothesized that plasma BCAAs are positively associated with CVD risk and evaluated whether this was dependent on an intermediate diagnosis of T2D. METHODS: Participants in the Women's Health Study prospective cohort were eligible if free of CVD at baseline blood collection (n=27 041). Plasma metabolites were measured via nuclear magnetic resonance spectroscopy. Multivariable Cox regression models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for BCAAs with incident CVD (myocardial infarction, stroke, and coronary revascularization). RESULTS: We confirmed 2207 CVD events over a mean 18.6 years of follow-up. Adjusting for age, body mass index, and other established CVD risk factors, total BCAAs were positively associated with CVD (per SD: HR, 1.13; 95% CI, 1.08-1.18), comparable to LDL-C (low-density lipoprotein cholesterol) with CVD (per SD: HR, 1.12; 95% CI, 1.07-1.17). BCAAs were associated with coronary events (myocardial infarction: HR, 1.16; 95% CI, 1.06-1.26; revascularization: HR, 1.17; 95% CI, 1.11-1.25), and borderline significant association with stroke (HR, 1.07; 95% CI, 0.99-1.15). The BCAA-CVD association was greater (P interaction=0.036) among women who developed T2D before CVD (HR, 1.20; 95% CI, 1.08-1.32) versus women without T2D (HR, 1.08; 95% CI, 1.03-1.14). Adjusting for LDL-C, an established CVD risk factor, did not attenuate these findings; however, adjusting for HbA1c and insulin resistance eliminated the associations of BCAAs with CVD. CONCLUSIONS: Circulating plasma BCAAs were positively associated with incident CVD in women. Impaired BCAA metabolism may capture the long-term risk of the common cause underlying T2D and CVD.
Palavras-chave
amino acids, blood pressure, isoleucine, metabolomics, valine
URI
https://observatorio.fm.usp.br/handle/OPI/28508
Referências
  1. [Anonymous], 1997, DIABETES CARE, P1183, DOI 10.2337/DIACARE.20.7.1183
  2. Atiya M, 2003, STROKE, V34, P565, DOI 10.1161/01.STR.0000054159.21017.7C
  3. Block G, 2006, EPIDEMIOLOGY, V17, P404, DOI 10.1097/01.ede.0000220655.53323.c9
  4. Buring JE, 1992, J MYOCARDIAL ISCHEMI, V4, P27
  5. Carayol M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0135437
  6. Chiuve SE, 2012, J NUTR, V142, P1009, DOI 10.3945/jn.111.157222
  7. COLDITZ GA, 1986, AM J EPIDEMIOL, V123, P894, DOI 10.1093/oxfordjournals.aje.a114319
  8. Dugani SB, 2016, JAMA CARDIOL, V1, P136, DOI 10.1001/jamacardio.2016.0096
  9. Ferguson JF, 2016, CLIN CHEM, V62, P545, DOI 10.1373/clinchem.2016.254318
  10. Freedman LS, 2014, AM J EPIDEMIOL, V180, P172, DOI 10.1093/aje/kwu116
  11. Gavin JR, 2000, DIABETES CARE, V23, pS4
  12. Guasch-Ferre M, 2016, DIABETES CARE, V39, P833, DOI 10.2337/dc15-2251
  13. Harada PHN, 2017, J CLIN LIPIDOL, V11, P1257, DOI 10.1016/j.jacl.2017.06.008
  14. JARRETT RJ, 1984, DIABETOLOGIA, V26, P99
  15. Jeyarajah EJ, 2006, CLIN LAB MED, V26, P847, DOI 10.1016/j.cll.2006.07.006
  16. Lawler PR, 2017, CLIN CHEM, V63, P870, DOI 10.1373/clinchem.2016.264515
  17. Lawler PR, 2016, CIRC RES, V118, P1106, DOI 10.1161/CIRCRESAHA.115.308078
  18. Lee CC, 2016, DIABETES CARE, V39, P582, DOI 10.2337/dc15-2284
  19. Lin J, 2006, CANCER RES, V66, P2869, DOI 10.1158/0008-5472.CAN-05-3922
  20. Liu SM, 2006, DIABETES, V55, P2856, DOI 10.2337/db06-0456
  21. Lotta LA, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002179
  22. Magnusson M, 2013, EUR HEART J, V34, P1982, DOI 10.1093/eurheartj/ehs424
  23. Mangge H, 2016, J NUTR BIOCHEM, V32, P123, DOI 10.1016/j.jnutbio.2016.02.007
  24. Mels CM, 2013, AMINO ACIDS, V45, P1405, DOI 10.1007/s00726-013-1611-0
  25. Mora S, 2006, JAMA-J AM MED ASSOC, V295, P1412, DOI 10.1001/jama.295.12.1412
  26. Neishabouri SH, 2015, AMINO ACIDS, V47, P1167, DOI 10.1007/s00726-015-1944-y
  27. Newgard CB, 2012, CELL METAB, V15, P606, DOI 10.1016/j.cmet.2012.01.024
  28. Newgard CB, 2009, CELL METAB, V9, P311, DOI 10.1016/j.cmet.2009.02.002
  29. Preiss D, 2016, DIABETIC MED, V33, P1569, DOI 10.1111/dme.13097
  30. REAVEN GM, 1988, DIABETES, V37, P1595, DOI 10.2337/diabetes.37.12.1595
  31. Rhodes ET, 2007, DIABETES CARE, V30, P141, DOI 10.2337/dc06-1142
  32. Ridker PM, 2005, NEW ENGL J MED, V352, P1293, DOI 10.1056/NEJMoa050613
  33. Ruiz-Canela M, 2016, CLIN CHEM, V62, P582, DOI 10.1373/clinchem.2015.251710
  34. Shah SH, 2012, AM HEART J, V163, P844, DOI 10.1016/j.ahj.2012.02.005
  35. Shah SH, 2010, CIRC-CARDIOVASC GENE, V3, P207, DOI 10.1161/CIRCGENETICS.109.852814
  36. STERN MP, 1995, DIABETES, V44, P369, DOI 10.2337/diabetes.44.4.369
  37. Sun HP, 2016, BBA-MOL BASIS DIS, V1862, P2270, DOI 10.1016/j.bbadis.2016.09.009
  38. Townsend MK, 2013, CLIN CHEM, V59, P1657, DOI 10.1373/clinchem.2012.199133
  39. Wang TJ, 2011, NAT MED, V17, P448, DOI 10.1038/nm.2307
  40. WILLETT WC, 1985, AM J EPIDEMIOL, V122, P51, DOI 10.1093/oxfordjournals.aje.a114086
  41. Wolak-Dinsmore J, 2018, CLIN BIOCHEM, V54, P92, DOI 10.1016/j.clinbiochem.2018.02.001
  42. WOLF AM, 1994, INT J EPIDEMIOL, V23, P991, DOI 10.1093/ije/23.5.991
  43. Wurtz P, 2015, CIRCULATION, V131, P774, DOI 10.1161/CIRCULATIONAHA.114.013116
  44. Yang PP, 2016, LIPIDS HEALTH DIS, V15, DOI 10.1186/s12944-016-0291-7
  45. Yang RY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0099598
  46. Zhang SMM, 2005, ANN INTERN MED, V142, P425, DOI 10.7326/0003-4819-142-6-200503150-00008

Coleções
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - ODS/03