Impact of the Severity of End-Stage Liver Disease in Cardiac Remodeling

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SILVESTRE, O. M. FMUSP-HC
BACAL, F. FMUSP-HC
FARIAS, A. Q. FMUSP-HC
ANDRADE, J. L. FMUSP-HC
FURTADO, M. FMUSP-HC
PUGLIESE, V. FMUSP-HC
ANDRAUS, W. FMUSP-HC
RAMOS, D. S. FMUSP-HC
BELLETI, E.
ALBUQUERQUE, L. A. C. FMUSP-HC
CARRILHO, F. J. FMUSP-HC
dc.date.issued 2012
dc.identifier.citation JOURNAL OF HEART AND LUNG TRANSPLANTATION, v.31, n.4, suppl.S, p.S152-S152, 2012
dc.identifier.issn 1053-2498
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/2884
dc.description.abstract Purpose: The impact of end-stage liver disease (ESLD) in cardiac remodeling of patients with cirrhosis is unknown. Our aim was to correlate the severity of ESLD with morphologic and functional heart changes. Methods and Materials: 184 patients underwent a protocol providing data on the severity of ESLD and undergoing echocardiography to assess the diameters of the left atrium and right ventricle; the systolic and diastolic diameters of the left ventricle, interventricular septum, and posterior wall of the left ventricle; systolic pulmonary artery pressure; ejection fraction; and diastolic function. Severity of ESLD was assessed by the Model for End-Stage Liver Disease (MELD) score. Results: Left-atrial diameter (r=0.323; IC 95% 0.190-0.455; p<0.001), left-ventricular diastolic diameter (r=0.177; IC 95% 0.033-0.320; p=0.01) and systolic pulmonary artery pressure (r=0.185; IC 95% 0.036-0.335; p=0.02) significantly correlated with MELD score. Patients with MELD >16 had significantly higher left-atrial diameter and systolic pulmonary artery pressure, compared with patients with MELD scores <16 points. Conclusions: Changes in cardiac structure and function correlate with the severity of ESLD.
dc.language.iso eng
dc.publisher ELSEVIER SCIENCE INC
dc.relation.ispartof Journal of Heart and Lung Transplantation
dc.rights restrictedAccess
dc.title Impact of the Severity of End-Stage Liver Disease in Cardiac Remodeling
dc.type conferenceObject
dc.rights.holder Copyright ELSEVIER SCIENCE INC
dc.description.conferencedate APR 17-21, 2012
dc.description.conferencelocal Prague, CZECH REPUBLIC
dc.description.conferencename 32nd Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation/Meeting of the ISHLT Academy - Core Competencies in Mechanical Circulatory Support
dc.description.group LIM/07
dc.description.group LIM/37
dc.description.group LIM/11
dc.type.category meeting abstract
dc.type.version publishedVersion
hcfmusp.author SILVESTRE, O. M.:HC:INCOR
hcfmusp.author BACAL, F.:HC:INCOR
hcfmusp.author FARIAS, A. Q.:FM:MGT
hcfmusp.author ANDRADE, J. L.:HC:INRAD
hcfmusp.author FURTADO, M.:HC:INRAD
hcfmusp.author PUGLIESE, V.:HC:ICHC
hcfmusp.author ANDRAUS, W.:HC:ICHC
hcfmusp.author RAMOS, D. S.:HC:ICHC
hcfmusp.author ALBUQUERQUE, L. A. C.:FM:MGT
hcfmusp.author CARRILHO, F. J.:FM:MGT
hcfmusp.author.external · BELLETI, E.:Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
hcfmusp.origem.id WOS:000302207900429
hcfmusp.publisher.city NEW YORK
hcfmusp.publisher.country USA
dc.description.index MEDLINE
hcfmusp.citation.wos 0
hcfmusp.affiliation.country Brasil


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